Total synthesis of cis-sylvaticin

被引：27

作者：

Brown, Lynda J. ^{[1
]}

Spurr, Ian B. ^{[1
]}

Kemp, Stephen C. ^{[1
]}

Camp, Nicholas P. ^{[2
]}

Gibson, Karl R. ^{[3
]}

Brown, Richard C. D. ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

[2] Erl Wood Manor, Lilly Res Ctr, Surrey GU20 6PH, England

[3] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1021/ol800767e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric total synthesis of (+)-cis-sylvaticin is described. Key steps include the use of permanganate-mediated oxidative cyclization of 1,5-dienes to synthesize the two major fragments 2 and 3 and a catalytically efficient tethered RCM to unite these THF-containing fragments. In addition, t-BuP4 base was found to reliably promote rapid alkylation of the butenolide precursor fragment 4.

引用

页码：2489 / 2492

页数：4

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