Activatable fluorescent probes for tumour-targeting imaging in live mice

被引：44
作者：
Razkin, Jesus
Josserand, Veronique
Boturyn, Didier
Jin, Zhao-hui
Dumy, Pascal
Favrot, Marie
Coll, Jean-Luc
Texier, Isabelle
机构：
[1] LEDSS, UMR CNRS 5616, 38041 Grenoble Cedex 9
[2] LETI/DTBS CEA Grenoble, 38054 Grenoble Cedex 9
[3] INSERM U578, Institut Albert Bonniot
[4] ANIMAGE-CREATIS, Bâtiment CERMEP, 69677 Bron Cedex
来源：
CHEMMEDCHEM | 2006年 / 1卷 / 10期
关键词：
Fluorescent probes; Imaging agents; Molecular recognition; Peptide scaffold;
D O I：
10.1002/cmdc.200600118
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Lighting up tumours in vivo: Activatable probes are designed to image tumour targets and cell internalisation in mice, with improved image contrast. These activatable probes are built on a cycloclecapeptide template with two independent functional domains. The cell-targeting domain allows a multimeric presentation of the RGD motif, and the imaging domain is composed of a dye and a quencher, separated by an intracellular cleavable disulfide bound.
引用
收藏
页码：1069 / +
页数：5
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