Critical Roles of IL-33/ST2 Pathway in Neurological Disorders

被引：23

作者：

Isnadi, Mohammad Faruq Abd Rachman ^{[1
]}

Chin, Voon Kin ^{[2
]}

Abd Majid, Roslaini ^{[2
]}

Lee, Tze Yan ^{[3
]}

Abdullah, Maizaton Atmadini ^{[3
]}

Omenesa, Ramatu Bello ^{[1
]}

Ibraheem, Zaid Osamah ^{[1
]}

Basir, Rusliza ^{[1
]}

机构：

[1] Univ Putra Malaysia, Dept Human Anat, Fac Med & Hlth Sci, Serdang, Malaysia

[2] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Med Microbiol & Parasitol, Serdang, Malaysia

[3] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Pathol, Serdang, Malaysia

来源：

MEDIATORS OF INFLAMMATION | 2018年 / 2018卷

关键词：

RECEPTOR ACCESSORY PROTEIN; ST2; GENE-PRODUCT; MULTIPLE-SCLEROSIS; CYTOKINE PRODUCTION; NATIONAL INSTITUTE; ALZHEIMERS-DISEASE; MEDICAL PROGRESS; CEREBRAL MALARIA; DUAL FUNCTION; VARIANT FORM;

D O I：

10.1155/2018/5346413

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro-and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with ST2 variants. IL-33 is a potent inducer for the Th2 immune response which includes defence mechanism in brain diseases. Thus, in this paper, we review the biological features of IL-33 and the critical roles of IL-33/ST2 pathway in selected neurological disorders including Alzheimer's disease, multiple sclerosis, and malaria infection to discuss the involvement of IL-33/ST2 pathway during these brain diseases and its potential as future immunotherapeutic agents or for intervention purposes.

引用

页数：9

共 90 条

[1] IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells [J].

Ali, Shafaqat ;

Hubert, Michael ;

Kollewe, Christian ;

Bischoff, Stephan C. ;

Falk, Werner ;

Martin, Michael U. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) :18660-18665

[2] The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB-Stimulated Gene Transcription [J].

Ali, Shafaqat ;

Mohs, Antje ;

Thomas, Meike ;

Klare, Jan ;

Ross, Ralf ;

Schmitz, Michael Lienhard ;

Martin, Michael Uwe .

JOURNAL OF IMMUNOLOGY, 2011, 187 (04) :1609-1616

[3] Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system [J].

Allan, Debbie ;

Fairlie-Clarke, Karen J. ;

Elliott, Christina ;

Schuh, Cornelia ;

Barnett, Susan C. ;

Lassmann, Hans ;

Linnington, Christopher ;

Jiang, Hui-Rong .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2016, 4 :75

[4] Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules [J].

Baekkevold, ES ;

Roussigné, M ;

Yamanaka, T ;

Johansen, FE ;

Jahnsen, FL ;

Amalric, F ;

Brandtzaeg, P ;

Erard, M ;

Haraldsen, G ;

Girard, JP .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (01) :69-79

[5]

Basir R, 2012, IRAN J PARASITOL, V7, P62

[6] IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells [J].

Besnard, Anne-Gaelle ;

Guabiraba, Rodrigo ;

Niedbala, Wanda ;

Palomo, Jennifer ;

Reverchon, Flora ;

Shaw, Tovah N. ;

Couper, Kevin N. ;

Ryffel, Bernhard ;

Liew, Foo Y. .

PLOS PATHOGENS, 2015, 11 (02)

[7] The Essential Role of Single Ig IL-1 Molecule/Toll IL-1R8 in Regulation Immune Response [J].

Bulek, Katarzyna ;

Swaidani, Shadi ;

Qin, Jinzhong ;

Lu, Yi ;

Gulen, Muhammet F. ;

Herjan, Tomasz ;

Min, Booki ;

Kastelein, Robert A. ;

Aronica, Mark ;

Kosz-Vnenchak, Magdalena ;

Li, Xiaoxia .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :2601-2609

[8] IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo [J].

Carriere, Virginie ;

Roussel, Lucie ;

Ortega, Nathalie ;

Lacorre, Delphine-Armelle ;

Americh, Laure ;

Aguilar, Luc ;

Bouche, Gerard ;

Girard, Jean-Philippe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (01) :282-287

[9] Revisiting the framework of the National Institute on Aging-Alzheimer's Association diagnostic criteria [J].

Carrillo, Maria C. ;

Dean, Robert A. ;

Nicolas, Francois ;

Miller, David S. ;

Berman, Robert ;

Khachaturian, Zaven ;

Bain, Lisa J. ;

Schindler, Rachel ;

Knopman, David .

ALZHEIMERS & DEMENTIA, 2013, 9 (05) :594-601

[10] The Development of New Therapeutics for Alzheimer's Disease [J].

Carter, M. D. ;

Simms, G. A. ;

Weaver, D. F. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 88 (04) :475-486

← 1 2 3 4 5 6 7 8 9 →