Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

被引：128

作者：

de Theije, Caroline G. M. ^{[1
]}

Wu, Jiangbo ^{[1
]}

da Silva, Sofia Lopes ^{[1
,2
]}

Kamphuis, Patrick J. ^{[1
,2
]}

Garssen, Johan ^{[1
,3
]}

Korte, S. Mechiel ^{[1
]}

Kraneveld, Aletta D. ^{[1
]}

机构：

[1] Univ Utrecht, Div Pharmacol, Utrecht Inst Pharmaceut Sci, Fac Sci, NL-3584 CG Utrecht, Netherlands

[2] Danone Res, Nutricia Adv Med Nutr, Ctr Specialised Nutr, Wageningen, Netherlands

[3] Danone Res, Immunol Platform, Ctr Specialised Nutr, Wageningen, Netherlands

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2011年 / 668卷

关键词：

Autism spectrum disorder; Gastrointestinal disturbances; Neuroimmune interactions; Gut-brain axis; NECROSIS-FACTOR-ALPHA; MICROVASCULAR ENDOTHELIAL-CELLS; POLYUNSATURATED FATTY-ACIDS; WHOLE-BLOOD SEROTONIN; ALTERNATIVE MEDICINE; GASTROINTESTINAL SYMPTOMS; IMMUNE-SYSTEM; 5-HYDROXYINDOLEACETIC ACID; DIETARY INTERVENTION; YOUNG-CHILDREN;

D O I：

10.1016/j.ejphar.2011.07.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy. (C) 2011 Published by Elsevier B.V.

引用

页码：S70 / S80

页数：11

共 163 条

[1] Gastrointestinal flora and gastrointestinal status in children with autism-comparisons to typical children and correlation with autism severity [J].

Adams, James B. ;

Johansen, Leah J. ;

Powell, Linda D. ;

Quig, David ;

Rubin, Robert A. .

BMC GASTROENTEROLOGY, 2011, 11

[2] Gut microbiota and development of atopic eczema in 3 European birth cohorts [J].

Adlerberth, Ingegerd ;

Strachan, David P. ;

Matricardi, Paolo M. ;

Ahrne, Siv ;

Orfei, Lia ;

Aberg, Nils ;

Perkin, Michael R. ;

Tripodi, Salvatore ;

Hesselmar, Bill ;

Saalman, Robert ;

Coates, Anthony R. ;

Bonanno, Carmen L. ;

Panetta, Valentina ;

Wold, Agnes E. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (02) :343-350

[3] Constipation with acquired megarectum in children with autism [J].

Afzal, N ;

Murch, S ;

Thirrupathy, K ;

Berger, L ;

Fagbemi, A ;

Heuschkel, R .

PEDIATRICS, 2003, 112 (04) :939-942

[4] DOCOSAHEXAENOIC ACID STATUS AND DEVELOPMENTAL QUOTIENT OF HEALTHY TERM INFANTS [J].

AGOSTONI, C ;

RIVA, E ;

TROJAN, S ;

BELLU, R ;

GIOVANNINI, M .

LANCET, 1995, 346 (8975) :638-638

[5] Immune function of microglia [J].

Aloisi, F .

GLIA, 2001, 36 (02) :165-179

[6] WHOLE-BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS [J].

ANDERSON, GM ;

FREEDMAN, DX ;

COHEN, DJ ;

VOLKMAR, FR ;

HODER, EL ;

MCPHEDRAN, P ;

MINDERAA, RB ;

HANSEN, CR ;

YOUNG, JG .

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES, 1987, 28 (06) :885-900

[7] Neurotensin is increased in serum of young children with autistic disorder [J].

Angelidou, Asimenia ;

Francis, Konstantinos ;

Vasiadi, Magdalini ;

Alysandratos, Konstantinos-Dionysios ;

Zhang, Bodi ;

Theoharides, Athanasios ;

Lykouras, Lefteris ;

Sideri, Kyriaki ;

Kalogeromitros, Dimitrios ;

Theoharides, Theoharis C. .

JOURNAL OF NEUROINFLAMMATION, 2010, 7

[8]

[Anonymous], 2011, J PEDIATR GASTR NUTR, DOI DOI 10.1097/MPG.0b013e3181fb9e80

[9]

[Anonymous], ALLERGY DRUG DISCOV

[10]

[Anonymous], 2000, FORCE DSM 4 DSM 4 T, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr

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