A slow-cycling subpopulation of melanoma cells with highly invasive properties

被引：57

作者：

Perego, M. ^{[1
]}

Maurer, M. ^{[2
]}

Wang, J. X. ^{[1
]}

Shaffer, S. ^{[3
]}

Mueller, A. C. ^{[4
]}

Parapatics, K. ^{[4
]}

Li, L. ^{[1
]}

Hristova, D. ^{[1
]}

Shin, S. ^{[1
]}

Keeney, F. ^{[1
]}

Liu, S. ^{[5
]}

Xu, X. ^{[5
]}

Raj, A. ^{[3
]}

Jensen, J. K. ^{[6
]}

Bennett, K. L. ^{[4
]}

Wagner, S. N. ^{[2
]}

Somasundaram, R. ^{[1
]}

Herlyn, M. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Melanoma Res Ctr, 3601 Spruce St, Philadelphia, PA 19104 USA

[2] Med Univ Vienna, Div Immunol Allergy & Infect Dis, Vienna, Austria

[3] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[4] Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria

[5] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Aarhus Univ, Dept Mol Biol & Genet, Aarhus, Denmark

来源：

ONCOGENE | 2018年 / 37卷 / 03期

关键词：

BONE MORPHOGENETIC PROTEIN-1; PROTEASE NEXIN-1; PROGNOSTIC-SIGNIFICANCE; PLASMINOGEN-ACTIVATOR; SAMPLE PREPARATION; INITIATING CELLS; MESSENGER-RNA; LOW NUMBER; CANCER; EXPRESSION;

D O I：

10.1038/onc.2017.341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melanoma is a heterogeneous tumor with different subpopulations showing different proliferation rates. Slow-cycling cells were previously identified in melanoma, but not fully biologically characterized. Using the label-retention method, we identified a subpopulation of slow-cycling cells, defined as label-retaining cells (LRC), with strong invasive properties. We demonstrate through live imaging that LRC are leaving the primary tumor mass at a very early stage and disseminate to peripheral organs. Through global proteome analyses, we identified the secreted protein SerpinE2/protease nexin-1 as causative for the highly invasive potential of LRC in melanomas.

引用

页码：302 / 312

页数：11

共 75 条

[51] Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells [J].

Roesch, Alexander ;

Vultur, Adina ;

Bogeski, Ivan ;

Wang, Huan ;

Zimmermann, Katharina M. ;

Speicher, David ;

Koerbel, Christina ;

Laschke, Matthias W. ;

Gimotty, Phyllis A. ;

Philipp, Stephan E. ;

Krause, Elmar ;

Paetzold, Sylvie ;

Villanueva, Jessie ;

Krepler, Clemens ;

Fukunaga-Kalabis, Mizuho ;

Hoth, Markus ;

Bastian, Boris C. ;

Vogt, Thomas ;

Herlyn, Meenhard .

CANCER CELL, 2013, 23 (06) :811-825

[52] A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth [J].

Roesch, Alexander ;

Fukunaga-Kalabis, Mizuho ;

Schmidt, Elizabeth C. ;

Zabierowski, Susan E. ;

Brafford, Patricia A. ;

Vultur, Adina ;

Basu, Devraj ;

Gimotty, Phyllis ;

Vogt, Thomas ;

Herlyn, Meenhard .

CELL, 2010, 141 (04) :583-594

[53] Protease nexin-1 inhibits plasminogen activation-induced apoptosis of adherent cells [J].

Rossignol, P ;

Ho-Tin-Noé, B ;

Vranckx, R ;

Bouton, MC ;

Meilhac, O ;

Lijnen, HR ;

Guillin, MC ;

Michel, JB ;

Anglés-Cano, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (11) :10346-10356

[54]

Scott C F, 1985, Trans Assoc Am Physicians, V98, P344

[55] Mammalian BMP-1/tolloid-related metalloproteinases, including novel family member mammalian tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis [J].

Scott, IC ;

Blitz, IL ;

Pappano, WN ;

Imamura, Y ;

Clark, TG ;

Steiglitz, BM ;

Thomas, CL ;

Maas, SA ;

Takahara, K ;

Cho, KWY ;

Greenspan, DS .

DEVELOPMENTAL BIOLOGY, 1999, 213 (02) :283-300

[56] Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis [J].

Selzer-Plon, Joanna ;

Bornholdt, Jette ;

Friis, Stine ;

Bisgaard, Hanne C. ;

Lothe, Inger M. B. ;

Tveit, Kjell M. ;

Kure, Elin H. ;

Vogel, Ulla ;

Vogel, Lotte K. .

BMC CANCER, 2009, 9

[57] The Genetic Evolution of Melanoma from Precursor Lesions [J].

Shain, A. Hunter ;

Yeh, Iwei ;

Kovalyshyn, Ivanka ;

Sriharan, Aravindhan ;

Talevich, Eric ;

Gagnon, Alexander ;

Dummer, Reinhard ;

North, Jeffrey ;

Pincus, Laura ;

Ruben, Beth ;

Rickaby, William ;

D'Arrigo, Corrado ;

Robson, Alistair ;

Bastian, Boris C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (20) :1926-1936

[58] The serpins are an expanding superfamily of structurally similar but functionally diverse proteins - Evolution, mechanism of inhibition, novel functions, and a revised nomenclature [J].

Silverman, GA ;

Bird, PI ;

Carrell, RW ;

Church, FC ;

Coughlin, PB ;

Gettins, PGW ;

Irving, JA ;

Lomas, DA ;

Luke, CJ ;

Moyer, RW ;

Pemberton, PA ;

Remold-O'Donnell, E ;

Salvesen, GS ;

Travis, J ;

Whisstock, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (36) :33293-33296

[59] Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling [J].

Strickland, DK ;

Ranganathan, S .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (07) :1663-1670

[60] Protease nexin 1 and its receptor LRP modulate SHH signalling during cerebellar development [J].

Vaillant, Catherine ;

Michos, Odysse ;

Orolicki, Slobodanka ;

Brellier, Florence ;

Taieb, Sabrina ;

Moreno, Eliza ;

Te, Helene ;

Zeller, Rolf ;

Monard, Denis .

DEVELOPMENT, 2007, 134 (09) :1745-1754

← 1 2 3 4 5 6 7 8 →