The Great Debate at "Melanoma Bridge", Naples, December 7th, 2019

被引:1
作者
Ascierto, Paolo A. [1 ]
Agarwala, Sanjiv S. [2 ]
Eggermont, Alexander [3 ]
Gershenwald, Jeffrey E. [4 ]
Grob, Jean-Jacques [5 ]
Hamid, Omid [6 ]
Michielin, Olivier [7 ]
Postow, Michael [8 ,9 ]
Puzanov, Igor [10 ]
Zarour, Hassane M. [11 ]
Caraco, Corrado [12 ]
Testori, Alessandro [13 ]
机构
[1] Ist Nazl Tumori IRCCS Fdn G Pascale, Unit Melanoma Canc Immunotherapy & Innovat Therap, Via Mariano Semmola, I-80131 Naples, Italy
[2] Temple Univ, Sch Med, Philadelphia, PA 19122 USA
[3] Princess Maxima Ctr Res Directorate, NL-3584 CS Utrecht, Netherlands
[4] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol & Canc Biol, Houston, TX 77030 USA
[5] Aix Marseille Univ, Hop Timone, Marseille, France
[6] Angeles Clin & Res Inst, Santa Monica, CA USA
[7] CHU Vaudois, Precis Oncol Ctr, Oncol Dept, Oncol Serv, Lausanne, Switzerland
[8] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[9] Weill Cornell Med Coll, New York, NY USA
[10] Roswell Park Comprehens Canc Ctr, Buffalo, NY USA
[11] Univ Pittsburgh, Hillman Canc Ctr, Pittsburgh, PA USA
[12] Ist Nazl Tumori IRCCS Fdn G Pascale, Dept Melanoma Soft Tissue Muscle Skeletal & Head, Naples, Italy
[13] Fdn IRCCS Policlin San Matteo, Dermatol, Pavia, Italy
关键词
Melanoma; Staging immunotherapy; Anti-PD-1; Anti-CTLA-4; Targeted therapy; BRAF inhibitor; MEK inhibitor; Adjuvant; Neoadjuvant; STAGE-III MELANOMA; INTERDISCIPLINARY GUIDELINE; IPILIMUMAB; ANTI-PD-1; COMBINATION; NIVOLUMAB; SURVIVAL; DISCONTINUATION; PEMBROLIZUMAB; CHEMOTHERAPY;
D O I
10.1186/s12967-020-02340-w
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The Great Debate session at the 2019 Melanoma Bridge congress (December 5-7, Naples, Italy) featured counterpoint views from experts on five topical issues in melanoma. These were whether to choose local intratumoral treatment or systemic treatment, whether patients with stage IIIA melanoma require adjuvant therapy or not, whether treatment is better changed at disease progression or during stable disease, whether adoptive cell transfer (ACT) therapy is more appropriate used before or in combination with checkpoint inhibition therapy, and whether treatment can be stopped while the patient is still on response. As was the case for previous meetings, the debates were assigned by meeting Chairs. As such, positions taken by each of the melanoma experts during the debates may not have reflected their respective personal approach.
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页数:15
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