Haploidentical vs identical-sibling transplant for AML in remission: a multicenter, prospective study

被引：413

作者：

Wang, Yu ^{[1
]}

Liu, Qi-Fa ^{[2
]}

Xu, Lan-Ping ^{[1
]}

Liu, Kai-Yan ^{[1
]}

Zhang, Xiao-Hui ^{[1
]}

Ma, Xiao ^{[3
]}

Fan, Zhi-Ping ^{[2
]}

Wu, De-Pei ^{[3
]}

Huang, Xiao-Jun ^{[1
,4
]}

机构：

[1] Peking Univ, Inst Hematol, Peoples Hosp, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

[3] Soochow Univ, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

[4] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

来源：

BLOOD | 2015年 / 125卷 / 25期

基金：

中国国家自然科学基金;

关键词：

STEM-CELL TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; 1ST COMPLETE REMISSION; ACUTE MYELOGENOUS LEUKEMIA; DONOR LYMPHOCYTE INFUSION; BONE-MARROW TRANSPLANT; RISK ACUTE-LEUKEMIA; HEMATOPOIETIC TRANSPLANTATION; UNRELATED DONOR; MYCOPHENOLATE-MOFETIL;

D O I：

10.1182/blood-2015-02-627786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of HLA-identical sibling donor (ISD) hematopoietic stem cell transplantation (HSCT) on adults with intermediate-or high-risk acute myeloid leukemia (AML) in the first complete remission (CR1) are well established. Previous single-center studies have demonstrated similar survival after unmanipulated haploidentical donor (HID) vs ISD HSCT for hematologic malignancies. To test the hypothesis that haploidentical HSCT would be a valid option as postremission therapy for AML patients in CR1 lacking a matched donor, we designed a disease-specific, prospective, multi-center study. Between July 2010 and November 2013, 450 patients were assigned to undergo HID (231 patients) or ISD HSCT (219 patients) according to donor availability. Among HID and ISD recipients, the 3-year disease-free survival rate was 74% and 78% (P=.34), respectively; the overall survival rate was 79% and 82%(P=.36), respectively; cumulative incidences of relapse were 15% and 15% (P = .98); and those of the nonrelapse-mortality were 13% and 8% (P = .13), respectively. In conclusion, unmanipulated haploidentical HSCT achieves outcomes similar to those of ISD HSCT for AML patients in CR1. Such transplantation was demonstrated to be a valid alternative as postremission treatment of intermediate or high-risk AML patients in CR1 lacking an identical donor.

引用

页码：3956 / 3962

页数：7

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