Effect of obesity and type 2 diabetes, and glucose ingestion on circulating spexin concentration in adolescents

被引：49

作者：

Hodges, S. Konnar ^{[1
]}

Teague, April M. ^{[1
]}

Dasari, Paul S. ^{[1
]}

Short, Kevin R. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Sect Diabet & Endocrinol, Oklahoma City, OK 73190 USA

来源：

PEDIATRIC DIABETES | 2018年 / 19卷 / 02期

关键词：

biomarkers; cardiometabolic; children; metabolism; peptide; INSULIN-RESISTANCE; ENDOCRINE; CHILDREN; PREVALENCE; PEPTIDE; ORGAN;

D O I：

10.1111/pedi.12549

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Spexin is a novel peptide that has been reported to be down regulated in obese adults and children and in normoglycemic adults following glucose ingestion. Spexin may therefore have a role in metabolic regulation. The purpose of the current study was to determine the effect of obesity and type 2 diabetes (T2DM), and the effect of glucose ingestion on circulating spexin concentration in adolescents. Boys and girls (mean age 16 years old) classified as healthy normal weight (NW, n = 22), obese (Ob, n = 10), or obese with T2DM (n = 12) completed measurements of body composition, blood pressure, cardiorespiratory fitness, and blood concentrations of glucose, insulin, and lipids. The median fasting serum spexin concentration did not differ between groups (NW: 0.35; Ob: 0.38, T2DM: 0.34 ng/mL, respectively). In 10 NW participants who completed a standard oral glucose tolerance test, spexin concentration was unchanged at 30 and 120 minutes relative to the fasting baseline. Finally, spexin was not significantly correlated with any of the body composition, fitness, or blood biochemical measurements. These data do not support the proposed role of spexin as a metabolic regulator or biomarker of glucose control in adolescents.

引用

页码：212 / 216

页数：5

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