New maplexins F-I and phenolic glycosides from red maple (Acer rubrum) bark

被引：51

作者：

Yuan, Tao ^{[1
]}

Wan, Chunpeng ^{[1
,2
]}

Liu, Ke ^{[3
]}

Seeram, Navindra P. ^{[1
]}

机构：

[1] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Bioact Bot Res Lab, Kingston, RI 02881 USA

[2] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China

[3] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

TETRAHEDRON | 2012年 / 68卷 / 04期

关键词：

Acer rubrum; Red maple; Maplexins; alpha-Glucosidase inhibition; SYRUP; PHYTOCHEMICALS; ACERTANNIN; SACCHARUM; EXTRACTS; LIGNANS; PLANTS; L;

D O I：

10.1016/j.tet.2011.11.062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new gallotannins, maplexins F-I (1-4), two new phenolic glycosides, rubrumosides A-B (5,6), and eleven known compounds were isolated from red maple (Acer rubrum) bark. Their structures were elucidated based on spectroscopic analysis. The maplexins contained three galloylated derivatives attached to different positions of 1,5-anhydro-glucitol and were 10-20 fold more potent alpha-glucosidase inhibitors than the clinical drug, Acarbose (IC50=7-16 vs 161 mu M), in vitro. These results support previous data suggesting that gallotannins are the main contributors to the alpha-glucosidase inhibitory activities of maple plant part extracts and that three substituents on the 1,5-anhydro-glucitol moiety are important for activity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：959 / 964

页数：6

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