A new efficient synthesis of isothiocyanates from amines using di-tert-butyl dicarbonate

被引：145

作者：

Munch, Henrik ^{[1
]}

Hansen, Jon S. ^{[1
]}

Pittelkow, Michael ^{[1
]}

Christensen, Jorn B. ^{[1
]}

Boas, Ulrik ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark

[2] Tech Univ Denmark, Natl Vet Inst, DK-1790 Copenhagen, Denmark

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 19期

关键词：

isothiocyanate; di-tert-butyl dicarbonate; thiourea; amine;

D O I：

10.1016/j.tetlet.2008.03.045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl and aryl amines are converted smoothly to the corresponding isothiocyanates via the dithiocarbamates in good to excellent yields using di-tert-butyl dicarbonate (Boc(2)O) and 1-3 mol% of DMAP or DABCO as catalyst. As most of the byproducts are volatile, the work-up involves simple evaporation of the reaction mixture. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3117 / 3119

页数：3

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