Cytokine Release Syndrome and Associated Acute Toxicities in Pediatric Patients Undergoing Immune Effector Cell Therapy or Hematopoietic Cell Transplantation

被引：13

作者：

Baumeister, Susanne H. C. ^{[1
,2
,3
]}

Mohan, Gopi S. ^{[1
,3
,4
]}

Elhaddad, Alaa ^{[5
]}

Lehmann, Leslie ^{[1
,2
,3
]}

机构：

[1] Boston Childrens Hosp, Div Pediat Hematol Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Div Pediat Crit Care, Boston, MA 02114 USA

[5] Childrens Canc Hosp Egypt, Natl Canc Inst Cairo, Cairo, Egypt

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

cytokine release syndrome (CRS); immune effector cell associated neurotoxicity syndrome (ICANS); immune effector cells (IEC); CAR T cells; blinatumomab; pediatric hematopoietic cell transplantation (HCT); haploidentical cell transplantation (Haplo-HCT); ACUTE LYMPHOBLASTIC-LEUKEMIA; RECEPTOR T-CELLS; TERM-FOLLOW-UP; FREE SURVIVAL; YOUNG-ADULTS; BLINATUMOMAB; MANAGEMENT; CHILDREN; TOCILIZUMAB; GUIDELINES;

D O I：

10.3389/fonc.2022.841117

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune effector cells (IEC) are a powerful and increasingly targeted tool, particularly for the control and eradication of malignant diseases. However, the infusion, expansion, and persistence of autologous or allogeneic IEC or engagement of endogenous immune cells can be associated with significant systemic multi-organ toxicities. Here we review the signs and symptoms, grading and pathophysiology of immune-related toxicities arising in the context of pediatric immunotherapies and haploidentical T cell replete Hematopoietic Cell Transplantation (HCT). Principles of management are discussed with particular focus on the intersection of these toxicities with the requirement for pediatric critical care level support.

引用

页数：16

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