Gene expression - The amazing demethylase

被引：46

作者：

Cedar, H ^{[1
]}

Verdine, GL

机构：

[1] Hebrew Univ Jerusalem, Sch Med, Dept Cellular Biochem, IL-91120 Jerusalem, Israel

[2] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

[3] Harvard Univ, Inst Chem & Cell Biol, Cambridge, MA 02138 USA

来源：

NATURE | 1999年 / 397卷 / 6720期

关键词：

D O I：

10.1038/17492

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA methylation is important for repressing gene expression, and much is known about how methyl groups are added to DNA. But little has been done to work out how they're taken off again. Now, a hitherto unknown gene has been cloned, which encodes a protein that seems to catalyse demethylation by directly removing the methyl groups from 5-methyl-cytosine.

引用

页码：568 / 569

页数：2

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