Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

被引：145

作者：

Joseph, Sarah B. ^{[1
,2
]}

Swanstrom, Ronald ^{[2
,3
,4
]}

Kashuba, Angela D. M. ^{[4
,5
]}

Cohen, Myron S. ^{[1
,4
,6
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, UNC Ctr AIDS Res, Chapel Hill, NC 27599 USA

[5] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[6] Univ N Carolina, Inst Global Hlth & Infect Dis, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; NEUTRALIZING ANTIBODY-RESPONSES; MANNOSE-BINDING LECTIN; FEMALE GENITAL-TRACT; DENDRITIC CELLS; HETEROSEXUAL TRANSMISSION; SEXUAL TRANSMISSION; VIRAL LOAD; TRANSMITTED/FOUNDER VIRUSES; MUCOSAL TRANSMISSION;

D O I：

10.1038/nrmicro3471

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 infection typically results from the transmission of a single viral variant, the transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information about the transmission bottlenecks and the selective pressures acting on the virus in the transmission fluid and in the recipient tissues. These studies reveal that T/F virus phenotypes are shaped by stochastic and selective forces that restrict transmission and may be targets for prevention strategies. In this Review, we highlight how studies of T/F viruses contribute to a better understanding of the biology of HIV-1 transmission and discuss how these findings affect HIV-1 prevention strategies.

引用

页码：414 / 425

页数：12

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