Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors

被引:15
作者
Hong, Bangxing [1 ]
Sahu, Upasana [1 ]
Mullarkey, Matthew P. [1 ]
Kaur, Balveen [1 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurosurg, Houston, TX 77030 USA
来源
VIRUSES-BASEL | 2022年 / 14卷 / 01期
基金
美国国家卫生研究院;
关键词
alphaherpesviruses; oncolytic virus; herpes simplex virus; replication; DEPENDENT PROTEIN-KINASE; MUTANT EXPRESSING ICP34.5; CENTRAL-NERVOUS-SYSTEM; GLIOBLASTOMA VIROTHERAPY; THERAPEUTIC-EFFICACY; GAMMA(1)34.5 PROTEIN; INTRATUMORAL SPREAD; ANTITUMOR EFFICACY; VIRAL REPLICATION; CRYSTAL-STRUCTURE;
D O I
10.3390/v14010118
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Oncolytic herpes simplex virus (oHSV) is a highly promising treatment for solid tumors. Intense research and development efforts have led to first-in-class approval for an oHSV for melanoma, but barriers to this promising therapy still exist that limit efficacy. The process of infection, replication and transmission of oHSV in solid tumors is key to obtaining a good lytic destruction of infected cancer cells to kill tumor cells and release tumor antigens that can prime anti-tumor efficacy. Intracellular tumor cell signaling and tumor stromal cells present multiple barriers that resist oHSV activity. Here, we provide a review focused on oncolytic HSV and the essential viral genes that allow for virus replication and spread in order to gain insight into how manipulation of these pathways can be exploited to potentiate oHSV infection and replication among tumor cells.
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页数:19
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