Pedigree analysis of factor XI deficiency in Japanese black cattle

被引：10

作者：

Ohba, Yasunori ^{[1
]}

Takasu, Masaki ^{[2
]}

Nishii, Naohito ^{[2
]}

Takeda, Eri ^{[1
]}

Maeda, Sadatoshi ^{[1
]}

Kunieda, Tetsuo ^{[3
]}

Kitagawa, Hitoshi ^{[1
]}

机构：

[1] Gifu Univ, Fac Appl Biol Sci, Dept Vet Med, Gifu 5011193, Japan

[2] Gifu Univ, United Grad Sch Vet Sci, Dept Vet Clin Med, Gifu 5011193, Japan

[3] Okayama Univ, Grad Sch Nat Sci & Technol, Okayama 7708530, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2008年 / 70卷 / 03期

关键词：

factor XI deficiency; gene frequency; Japanese black cattle;

D O I：

10.1292/jvms.70.297

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cattle with the factor XI deficiency. Results showed that the mutated allele of factor XI deficiency was retroactive in at least 6 or more generations of sires. Frequencies of the mutant gene were higher at 26.4% in total, and at 33.3% in sires. All 7 cattle with the homozygote of mutated allele were clinically normal, and showed no bleeding episodes. The mutated allele of factor XI deficiency might be widespread among Japanese black cattle.

引用

页码：297 / 299

页数：3

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