Viral vectors as vaccine platforms: from immunogenicity to impact

被引：138

作者：

Ewer, Katie J. ^{[1
]}

Lambe, Teresa ^{[1
]}

Rollier', Christine S. ^{[2
,3
]}

Spencer, Alexandra J. ^{[1
]}

Hill, Adrian V. S. ^{[1
,3
]}

Dorrell, Lucy ^{[3
,4
]}

机构：

[1] Univ Oxford, Jenner Inst, Oxford OX3 7DQ, England

[2] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford OX3 7LJ, England

[3] Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford OX1 2JD, England

[4] Univ Oxford, Nuffield Dept Med, Oxford OX3 7FZ, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2016年 / 41卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

T-CELL RESPONSES; PLASMODIUM-FALCIPARUM INFECTION; CHIMPANZEE ADENOVIRUS; TUBERCULOSIS VACCINE; PROTECTIVE EFFICACY; CLINICAL-ASSESSMENT; INFLUENZA VACCINE; VIRUS ANKARA; MALARIA; PROTEIN;

D O I：

10.1016/j.coi.2016.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viral vectors are the vaccine platform of choice for many pathogens that have thwarted efforts towards control using conventional vaccine approaches. Although the STEP trial encumbered development of recombinant human adenovirus vectors only a few years ago, replication-deficient simian adenoviruses have since emerged as a crucial component of clinically effective prime-boost regimens. The vectors discussed here elicit functionally relevant cellular and humoral immune responses, at extremes of age and in diverse populations. The recent Ebola virus outbreak highlighted the utility of viral vectored vaccines in facilitating a rapid response to public health emergencies. Meanwhile, technological advances in manufacturing to support scale-up of viral vectored vaccines have helped to consolidate their position as a leading approach to tackling 'old' and emerging infections.

引用

页码：47 / 54

页数：8

共 61 条

[1] Enhancing cellular immunogenicity of MVA-vectored vaccines by utilizing the F11L endogenous promoter [J].

Alharbi, Naif Khalaf ;

Spencer, Alexandra J. ;

Salman, Ahmed M. ;

Tully, Claire M. ;

Chinnakannan, Senthil K. ;

Lambe, Teresa ;

Yamaguchi, Yuko ;

Morris, Susan J. ;

Orubu, Toritse ;

Draper, Simon J. ;

Hill, Adrian V. S. ;

Gilbert, Sarah C. .

VACCINE, 2016, 34 (01) :49-55

[2]

[Anonymous], N ENGL J MED

[3]

[Anonymous], N ENGL J MED

[4] Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens [J].

Antrobus, Richard D. ;

Coughlan, Lynda ;

Berthoud, Tamara K. ;

Dicks, Matthew D. ;

Hill, Adrian V. S. ;

Lambe, Teresa ;

Gilbert, Sarah C. .

MOLECULAR THERAPY, 2014, 22 (03) :668-674

[5] Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses [J].

Antrobus, Richard D. ;

Berthoud, Tamara K. ;

Mullarkey, Caitlin E. ;

Hoschler, Katja ;

Coughlan, Lynda ;

Zambon, Maria ;

Hill, Adrian V. S. ;

Gilbert, Sarah C. .

MOLECULAR THERAPY, 2014, 22 (01) :233-238

[6] A T Cell-Inducing Influenza Vaccine for the Elderly: Safety and Immunogenicity of MVA-NP+M1 in Adults Aged over 50 Years [J].

Antrobus, Richard D. ;

Lillie, Patrick J. ;

Berthoud, Tamara K. ;

Spencer, Alexandra J. ;

McLaren, James E. ;

Ladell, Kristin ;

Lambe, Teresa ;

Milicic, Anita ;

Price, David A. ;

Hill, Adrian V. S. ;

Gilbert, Sarah C. .

PLOS ONE, 2012, 7 (10)

[7] Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission [J].

Balazs, Alejandro B. ;

Ouyang, Yong ;

Hong, Christin M. ;

Chen, Joyce ;

Nguyen, Steven M. ;

Rao, Dinesh S. ;

An, Dong Sung ;

Baltimore, David .

NATURE MEDICINE, 2014, 20 (03) :296-300

[8] Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys [J].

Barouch, Dan H. ;

Alter, Galit ;

Broge, Thomas ;

Linde, Caitlyn ;

Ackerman, Margaret E. ;

Brown, Eric P. ;

Borducchi, Erica N. ;

Smith, Kaitlin M. ;

Nkolola, Joseph P. ;

Liu, Jinyan ;

Shields, Jennifer ;

Parenteau, Lily ;

Whitney, James B. ;

Abbink, Peter ;

Ng'ang'a, David M. ;

Seaman, Michael S. ;

Lavine, Christy L. ;

Perry, James R. ;

Li, Wenjun ;

Colantonio, Arnaud D. ;

Lewis, Mark G. ;

Chen, Bing ;

Wenschuh, Holger ;

Reimer, Ulf ;

Piatak, Michael ;

Lifson, Jeffrey D. ;

Handley, Scott A. ;

Virgin, Herbert W. ;

Koutsoukos, Marguerite ;

Lorin, Clarisse ;

Voss, Gerald ;

Weijtens, Mo ;

Pau, Maria G. ;

Schuitemaker, Hanneke .

SCIENCE, 2015, 349 (6245) :320-324

[9] Extended Follow-Up Following a Phase 2b Randomized Trial of the Candidate Malaria Vaccines FP9 ME-TRAP and MVA ME-TRAP among Children in Kenya [J].

Bejon, Philip ;

Ogada, Edna ;

Mwangi, Tabitha ;

Milligan, Paul ;

Lang, Trudie ;

Fegan, Greg ;

Gilbert, Sarah C. ;

Peshu, Norbert ;

Marsh, Kevin ;

Hill, Adrian V. S. .

PLOS ONE, 2007, 2 (08)

[10] Adenoviral Vector Vaccination Induces a Conserved Program of CD8+ T Cell Memory Differentiation in Mouse and Man [J].

Bolinger, Beatrice ;

Sims, Stuart ;

Swadling, Leo ;

O'Hara, Geraldine ;

de Lara, Catherine ;

Baban, Dilair ;

Saghal, Natasha ;

Lee, Lian Ni ;

Marchi, Emanuele ;

Davis, Mark ;

Newell, Evan ;

Capone, Stefania ;

Folgori, Antonella ;

Barnes, Ellie ;

Klenerman, Paul .

CELL REPORTS, 2015, 13 (08) :1578-1588

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