Photo-Decomposable Sub-Micrometer Albumin Particles Cross-Linked by ortho-Nitrobenzyl Derivatives

被引：3
作者：
Li, Huiying [1 ]
Xiong, Yu [2 ,3 ]
Zhang, Yixian [1 ]
Tong, Weijun [1 ]
Georgieva, Radostina [2 ,3 ]
Baeumler, Hans [2 ,3 ]
Gao, Changyou [1 ,4 ]
机构：
[1] Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China
[2] Charite Univ Med Berlin, Inst Transfus Med, Charitepl 1, D-10117 Berlin, Germany
[3] Charite Univ Med Berlin, Berlin Brandenburg Ctr Regenerat Therapies, Charitepl 1, D-10117 Berlin, Germany
[4] Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Rege, Hangzhou 310030, Zhejiang, Peoples R China
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2017年 / 218卷 / 24期
关键词：
bovine serum albumin; decomposition; ortho-nitrobenzyl; photoresponsive particles; RELEASE; MICROCAPSULES; CAPSULES; MICELLES; DELIVERY; POLYMER;
D O I：
10.1002/macp.201700413
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Stimuli-responsive particles are widely used as carriers for on-demand delivery of drugs, genes, proteins, etc., due to their response to environmental stimuli. In this study, photoresponsive albumin sub-micrometer particles are fabricated by using ortho-nitrobenzyl derivative 4-bromomethyl-3-nitrobenzoic acid (BNBA) as a cross-linker. Bovine serum albumin (BSA)-doped MnCO3 particles are used as the sacrificial template, in which the BSA molecules are cross-linked by BNBA under the activation of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. After removal of MnCO3 particles by ethylene diamine tetraacetic acid, photoresponsive BSA-BNBA sub-micrometer particles are obtained. Since the C-N bond formed via reaction of benzyl bromide and amine is photocleavable, the particles can be decomposed upon UV irradiation at 365 nm under acidic environment. The loaded macromolecules can be released upon UV irradiation, exhibiting great potential applications of the particles in the field of controlled release.
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页数：6
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