Neutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantum

被引:0
|
作者
da Silva, Diogo Tiago [1 ,2 ]
Alves, Maria Luana [1 ,2 ]
Pereira Spada, Julio Cesar [1 ,2 ]
Viveiros da Silveira, Rita de Cassia [3 ]
Ferreira de Sousa Oliveira, Tricia Maria [2 ,4 ]
Starke-Buzetti, Wilma Aparecida [1 ]
机构
[1] Univ Estadual Paulista UNESP, Fac Engn Ilha Solteira, Dept Biol & Ciencia Anim, Ave Brasil 56, BR-15385000 Ilha Solteira, SP, Brazil
[2] Univ Sao Paulo, Programa Grad Epidemiol Expt Aplicada Zoonoses, Sao Paulo, SP, Brazil
[3] Univ Estadual Paulista UNESP, Inst Biotechnol, Botucatu, SP, Brazil
[4] Univ Sao Paulo, Dept Med Vet, Fac Engn Alimentos & Ciencia Anim FZEA, Pirassununga, SP, Brazil
来源
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA | 2018年 / 27卷 / 04期
基金
巴西圣保罗研究基金会;
关键词
Canine visceral leishmaniasis; intestinal tract; granulocytes; CANINE VISCERAL LEISHMANIASIS; GROWTH-FACTOR-BETA; GASTROINTESTINAL-TRACT; DONOVANI; EXPRESSION; IMMUNITY; SKIN; GRANULOCYTES; ASSOCIATION; DIAGNOSIS;
D O I
10.1590/S1984-296120180085
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Visceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophi Is, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. infantum amastigotes in the intestine; group 2 (G2, n=9), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). Granulocytic cells were counted in the crypt-villus unit (mucosa), submucosa, and muscle layer of the intestinal mucosa. Cell counts were higher in the intestinal wall of dogs from G2 followed by G1 and G3 (p <= 0.05). In G1, there was a low inverse correlation between parasite burden of the small intestine and granulocyte counts (r= -0.1, p <= 0.01). However, in G2 dogs, mast cell and eosinophil numbers showed positive correlation (r=0.85, p <= 0.01). The granulocytic cell hyperplasia observed in the intestine of L. infantum-infected dogs suggests that these cells may be involved in the cell-mediated immune response for parasite elimination.
引用
收藏
页码:430 / 438
页数:9
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