New potential antiscarring approaches

被引：9

作者：

Liu, Wei ^{[1
,2
,3
]}

Wu, Xiaoli ^{[1
]}

Gao, Zhen ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Plast & Reconstruct Surg, Shanghai Peoples Hosp 9, Sch Med, Shanghai 200011, Peoples R China

[2] Shanghai Res Inst Plast & Reconstruct Surg, Shanghai, Peoples R China

[3] Shanghai Tissue Engn Key Lab, Shanghai, Peoples R China

来源：

WOUND REPAIR AND REGENERATION | 2011年 / 19卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

ADENOVIRAL-MEDIATED OVEREXPRESSION; BONE-MARROW-CELLS; PULSED DYE-LASER; SCAR FORMATION; TGF-BETA; STEM-CELLS; HYPERTROPHIC SCARS; HYALURONIC-ACID; NEUTRALIZING ANTIBODY; DISTINGUISHES FETAL;

D O I：

10.1111/j.1524-475X.2011.00710.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Significant progress has been made in scar research in which an anti-transforming growth factor-beta strategy has already been translated from an experimental study to a clinical trial. However, scar reduction and elimination remain an unmet medical need because of the difficulty in its treatment. The authors of this article would like to propose several new potential antiscarring approaches for scar prevention including anti-transforming growth factor-beta, multifactor therapies, tissue regeneration, and tissue-engineered skin. In addition, scar remodeling is also proposed as an alternative new potential approach for scar therapy. We hope that some of these potential approaches might be translated into clinical scar therapies in the near future.

引用

页码：S22 / S31

页数：10

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