Triplex technology in studies of DNA damage, DNA repair, and mutagenesis

被引：68

作者：

Mukherjee, Anirban ^{[1
]}

Vasquez, Karen M. ^{[1
]}

机构：

[1] Univ Texas Austin, Dell Pediat Res Inst, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78723 USA

来源：

BIOCHIMIE | 2011年 / 93卷 / 08期

关键词：

Triplex-forming oligonucleotides; DNA damage; DNA repair; Triplex technology; Recombination; Mutagenesis; DNA structure; INTERSTRAND CROSS-LINKS; HELIX-FORMING OLIGONUCLEOTIDE; NUCLEOTIDE EXCISION-REPAIR; PEPTIDE NUCLEIC-ACIDS; DOUBLE-STRAND BREAKS; ANTICANCER DRUG CISPLATIN; SELECTABLE MAMMALIAN GENE; REPLICATION PROTEIN-A; HOMOLOGOUS RECOMBINATION; BINDING PROTEIN;

D O I：

10.1016/j.biochi.2011.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triplex-forming oligonucleotides (TFOs) can bind to the major groove of homopurine-homopyrimidine stretches of double-stranded DNA in a sequence-specific manner through Hoogsteen hydrogen bonding to form DNA triplexes. TFOs by themselves or conjugated to reactive molecules can be used to direct sequence-specific DNA damage, which in turn results in the induction of several DNA metabolic activities. Triplex technology is highly utilized as a tool to study gene regulation, molecular mechanisms of DNA repair, recombination, and mutagenesis. In addition, TFO targeting of specific genes has been exploited in the development of therapeutic strategies to modulate DNA structure and function. in this review, we discuss advances made in studies of DNA damage, DNA repair, recombination, and mutagenesis by using triplex technology to target specific DNA sequences. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：1197 / 1208

页数：12

共 161 条

[1] Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in Vivo
Alam, Md. Rowshon
Majumdar, Alokes
Thazhathveetil, Arun Kalliat
Liu, Su-Ting
Liu, Ji-Lan
Puri, Nitin
Cuenoud, Bernard
Sasaki, Shigeki
Miller, Paul S.
Seidman, Michael M.
[J]. BIOCHEMISTRY, 2007, 46 (35) : 10222 - 10233
[2] STRUCTURES FOR POLYNUCLEOTIDE COMPLEXES POLY(DA).POLY(DT) AND POLY(DT).POLY(DA).POLY(DT)
ARNOTT, S
SELSING, E
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1974, 88 (02) : 509 - +
[3] Conformational and thermodynamic properties of parallel intramolecular triple helices containing a DNA, RNA, or 2′-OMeDNA third strand
Asensio, JL
Carr, R
Brown, T
Lane, AN
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (48) : 11063 - 11070
[4] Thermodynamic, kinetic, and conformational properties of a parallel intermolecular DNA triplex containing 5′ and 3′ junctions
Asensio, JL
Dosanjh, HS
Jenkins, TC
Lane, AN
[J]. BIOCHEMISTRY, 1998, 37 (43) : 15188 - 15198
[5] Solution conformation of a parallel DNA triple helix with 5′ and 3′ triplex-duplex junctions
Asensio, JL
Brown, T
Lane, AN
[J]. STRUCTURE WITH FOLDING & DESIGN, 1999, 7 (01): : 1 - 11
[6] Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology
Babinet, C
Cohen-Tannoudji, M
[J]. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2001, 73 (03): : 365 - 383
[7] Breakpoints of gross deletions coincide with non-B DNA conformations
Bacolla, A
Jaworski, A
Larson, JE
Jakupciak, JP
Chuzhanova, N
Abeysinghe, SS
O'Connell, CD
Cooper, DN
Wells, RD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (39) : 14162 - 14167
[8] Asymmetric recognition of psoralen interstrand crosslinks by the nucleotide excision repair and the error-prone repair pathways
Barre, FX
Asseline, U
Harel-Bellan, A
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1999, 286 (05) : 1379 - 1387
[9] Covalent crosslinks introduced via a triple helix-forming oligonucleotide coupled to psoralen are inefficiently repaired
Barre, FX
Giovannangeli, C
Hélène, C
Harel-Bellan, A
[J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (03) : 743 - 749
[10] Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif
Basye, J
Trent, JO
Gao, DQ
Ebbinghaus, SW
[J]. NUCLEIC ACIDS RESEARCH, 2001, 29 (23) : 4873 - 4880

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