Prorenin anno 2008

被引：14
作者：
Danser, A. H. Jan [1 ]
Batenburg, Wendy W. [1 ]
van Esch, Joep H. M. [1 ]
Krop, Manne [1 ]
机构：
[1] Erasmus MC, Dept Internal Med, Div Vascular Pharmacol & Metab, NL-3015 GE Rotterdam, Netherlands
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2008年 / 86卷 / 06期
关键词：
(pro)renin receptor; renin; renin angiotensin system; diabetes; signaling; tissue angiotensin; renin inhibitor; receptor;
D O I：
10.1007/s00109-008-0318-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.
引用
收藏
页码：655 / 658
页数：4
相关论文
共 30 条
  • [11] Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats
    Kaneshiro, Y.
    Ichihara, A.
    Takemitsu, T.
    Sakoda, M.
    Suzuki, F.
    Nakagawa, T.
    Hayashi, M.
    Inagami, T.
    [J]. KIDNEY INTERNATIONAL, 2006, 70 (04) : 641 - 646
  • [12] Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats
    Kaneshiro, Yuki
    Ichihara, Atsuhiro
    Sakoda, Mariyo
    Takemitsu, Tornoko
    Nabi, A. H. M. Nurun
    Uddin, M. Nasir
    Nakagawa, Tsutornu
    Nishiyama, Akira
    Suzuki, Fumiaki
    Inagami, Tadashi
    Itoh, Hiroshi
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (06): : 1789 - 1795
  • [13] KROP M, 2008, IN PRESS CURR HYP RE
  • [14] Renin and prorenin disappearance in humans post-nephrectomy: evidence for binding?
    Krop, Manne
    de Bruyn, Jan H. B.
    Derkx, Frans H. M.
    Danser, Alexander H. J.
    [J]. FRONTIERS IN BIOSCIENCE, 2008, 13 : 3931 - 3939
  • [15] HALF-LIFE, HEMODYNAMIC, RENAL, AND HORMONAL EFFECTS OF PRORENIN IN CYNOMOLGUS MONKEYS
    LENZ, T
    SEALEY, JE
    MAACK, T
    JAMES, GD
    HEINRIKSON, RL
    MARION, D
    LARAGH, JH
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (04): : R804 - R810
  • [16] INCREASED PLASMA INACTIVE RENIN IN DIABETES-MELLITUS - A MARKER OF MICROVASCULAR COMPLICATIONS
    LUETSCHER, JA
    KRAEMER, FB
    WILSON, DM
    SCHWARTZ, HC
    BRYERASH, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (22) : 1412 - 1417
  • [17] Conformational changes in prorenin during renin inhibition in vitro and in vivo
    Ménard, J
    Guyene, TT
    Peyrard, S
    Azizi, M
    [J]. JOURNAL OF HYPERTENSION, 2006, 24 (03) : 529 - 534
  • [18] Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    Nguyen, G
    Delarue, F
    Burcklé, C
    Bouzhir, L
    Giller, T
    Sraer, JD
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (11) : 1417 - 1427
  • [19] Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats:: absence of prorenin-induced glomerulosclerosis
    Peters, Barbara
    Grisk, Olaf
    Becher, Bertram
    Wanka, Heike
    Kuttler, Beate
    Luedemann, Jan
    Lorenz, Gerd
    Rettig, Rainer
    Mullins, John J.
    Peters, Joerg
    [J]. JOURNAL OF HYPERTENSION, 2008, 26 (01) : 102 - 109
  • [20] Tissue activity of circulating prorenin
    Prescott, G
    Silversides, DW
    Reudelhuber, TL
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2002, 15 (03) : 280 - 285
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