Prorenin anno 2008

被引：14

作者：

Danser, A. H. Jan ^{[1
]}

Batenburg, Wendy W. ^{[1
]}

van Esch, Joep H. M. ^{[1
]}

Krop, Manne ^{[1
]}

机构：

[1] Erasmus MC, Dept Internal Med, Div Vascular Pharmacol & Metab, NL-3015 GE Rotterdam, Netherlands

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2008年 / 86卷 / 06期

关键词：

(pro)renin receptor; renin; renin angiotensin system; diabetes; signaling; tissue angiotensin; renin inhibitor; receptor;

D O I：

10.1007/s00109-008-0318-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.

引用

页码：655 / 658

页数：4

共 30 条

[1] Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor [J].

Batenburg, Wendy W. ;

Krop, Manne ;

Garrelds, Ingrid M. ;

de Vries, Rene ;

de Bruin, Rene J. A. ;

Burckle, Celine A. ;

Muller, Dominik N. ;

Bader, Michael ;

Nguyen, Genevieve ;

Danser, A. H. Jan .

JOURNAL OF HYPERTENSION, 2007, 25 (12) :2441-2453

[2] Elevated blood pressure and heart rate in human renin receptor transgenic rats [J].

Burcklé, CA ;

Danser, AHJ ;

Müller, DN ;

Garrelds, IM ;

Gasc, JM ;

Popova, E ;

Plehm, R ;

Peters, J ;

Bader, M ;

Nguyen, G .

HYPERTENSION, 2006, 47 (03) :552-556

[3] Renin, prorenin and the putative (pro)renin receptor [J].

Danser, AHJ ;

Deinum, J .

HYPERTENSION, 2005, 46 (05) :1069-1076

[4]

Danser AHJ, 2003, INT J BIOCHEM CELL B, V35, P759

[5]

Danser AHJ, 1998, J HYPERTENS, V16, P853

[6] SOURCE OF PLASMA PRORENIN IN EARLY AND LATE PREGNANCY - OBSERVATIONS IN A PATIENT WITH PRIMARY OVARIAN FAILURE [J].

DERKX, FHM ;

ALBERDA, AT ;

DEJONG, FH ;

ZEILMAKER, FH ;

MAKOVITZ, JW ;

SCHALEKAMP, MADH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 65 (02) :349-354

[7]

FELDT S, 2008, IN PRESS HYPERTENSIO

[8] Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms [J].

Huang, Y ;

Wongamorntham, S ;

Kasting, J ;

McQuillan, D ;

Owens, RT ;

Yu, L ;

Noble, NA ;

Border, W .

KIDNEY INTERNATIONAL, 2006, 69 (01) :105-113

[9] Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle'' region for nonproteolytic activation of prorenin [J].

Ichihara, A ;

Hayashi, M ;

Kaneshiro, Y ;

Suzuki, F ;

Nakagawa, T ;

Tada, Y ;

Koura, Y ;

Nishiyama, A ;

Okada, H ;

Uddin, MN ;

Nabi, AHMN ;

Ishida, Y ;

Inagami, T ;

Saruta, T .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (08) :1128-1135

[10] Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice [J].

Ichihara, Atsuhiro ;

Suzuki, Fumiaki ;

Nakagawa, Tsutomu ;

Kaneshiro, Yuki ;

Takemitsu, Tomoko ;

Sakoda, Mariyo ;

Nabi, A. H. M. Nurun ;

Nishiyama, Akira ;

Sugaya, Takeshi ;

Hayashi, Matsuhiko ;

Inagami, Tadashi .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (07) :1950-1961

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