Prorenin anno 2008

被引：14
作者：
Danser, A. H. Jan [1 ]
Batenburg, Wendy W. [1 ]
van Esch, Joep H. M. [1 ]
Krop, Manne [1 ]
机构：
[1] Erasmus MC, Dept Internal Med, Div Vascular Pharmacol & Metab, NL-3015 GE Rotterdam, Netherlands
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2008年 / 86卷 / 06期
关键词：
(pro)renin receptor; renin; renin angiotensin system; diabetes; signaling; tissue angiotensin; renin inhibitor; receptor;
D O I：
10.1007/s00109-008-0318-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.
引用
收藏
页码：655 / 658
页数：4
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