IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response

被引：68
|
作者：
Leyva, L
Fernández, O
Fedetz, M
Blanco, E
Fernández, VE
Oliver, B
León, A
Pinto-Medel, MJ
Mayorga, C
Guerrero, M
Luque, G
Alcina, A
Matesanz, F
机构：
[1] Hosp Civil, Lab Invest, Malaga 29009, Spain
[2] Hosp Carlos Haya, Serv Neurol, Inst Neurociencias Clin, Malaga 29010, Spain
[3] Hosp Clin San Cecilio, Granada 18012, Spain
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 163卷 / 1-2期
关键词：
type I interferon receptor; polymorphism; multiple sclerosis; association; treatment;
D O I：
10.1016/j.jneuroim.2005.02.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFN treatment response in a group of 147 patients and 210 controls undergoing interferon therapy during the last 2 years. Only the 18417 and the 11876 SNPs showed an association with disease susceptibility (p = 0.001 and 0.035, respectively) although no differential genotype distribution were observed between interferon responders and non-responder MS patients. No alteration of the expression level of IFNAR-1 was observed with respect to the -408 genotypes or to interferon treatment response. These data suggest a role for the IFNAR pathway in susceptibility to MS. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
相关论文
共 50 条
  • [41] Pro-inflammatory cytokine and chemokine mRNA blood level in multiple sclerosis is related to treatment response and interferon-beta dose
    Cucci, Angele
    Barbero, Pierangelo
    Clerico, Marinella
    Ferrero, Bruno
    Versino, Elisabetta
    Contessa, Giulia
    Demercanti, Stefania
    Viglietta, Emanuela
    Di Liberto, Alessandra
    Vai, Alessandra Giai
    Durelli, Luca
    JOURNAL OF NEUROIMMUNOLOGY, 2010, 226 (1-2) : 150 - 157
  • [42] Brain atrophy as a non-response predictor to interferon-beta in relapsing-remitting multiple sclerosis
    Ignacio Rojas, Juan
    Patrucco, Liliana
    Miguez, Jimena
    Besada, Cristina
    Cristiano, Edgardo
    NEUROLOGICAL RESEARCH, 2014, 36 (07) : 615 - 618
  • [43] A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients
    Martire, Serena
    Navone, Nicole D.
    Montarolo, Francesca
    Perga, Simona
    Bertolotto, Antonio
    JOURNAL OF NEUROIMMUNOLOGY, 2016, 292 : 34 - 39
  • [44] Response to interferon-beta therapy in relapsing-remitting multiple sclerosis: a comparison of different clinical criteria
    Portaccio, E
    Zipoli, V
    Siracusa, G
    Sorbi, S
    Amato, MP
    MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (03) : 281 - 286
  • [45] Response to treatment with Interferon beta-1a in patients with relapsing-remitting multiple sclerosis
    Vazquez Gomez, Lazaro Aurelio
    Hidalgo Mesa, Carlos
    Broche Perez, Yunier
    Valdes Morales, Yanet
    MEDISUR-REVISTA DE CIENCIAS MEDICAS DE CIENFUEGOS, 2022, 20 (05): : 825 - 833
  • [46] Transcriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis
    Michael Gurevich
    Gadi Miron
    Rina Zilkha Falb
    David Magalashvili
    Mark Dolev
    Yael Stern
    Anat Achiron
    BMC Neurology, 15
  • [47] Transcriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis
    Gurevich, Michael
    Miron, Gadi
    Falb, Rina Zilkha
    Magalashvili, David
    Dolev, Mark
    Stern, Yael
    Achiron, Anat
    BMC NEUROLOGY, 2015, 15
  • [48] Interferon-beta treatment and active replication of the JC virus in relapsing-remitting multiple sclerosis patients
    Alvarez-Lafuente, R.
    Garcia-Montojo, M.
    De Las Heras, V.
    Bartolome, M.
    Arroyo, R.
    EUROPEAN JOURNAL OF NEUROLOGY, 2007, 14 (02) : 233 - 236
  • [49] Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers
    Vera Pravica
    Dusan Popadic
    Emina Savic
    Milos Markovic
    Jelena Drulovic
    Marija Mostarica-Stojkovic
    Immunologic Research, 2012, 52 : 42 - 52
  • [50] Preserved in vivo response to interferon-alpha in multiple sclerosis patients with neutralising antibodies against interferon-beta (REPAIR study)
    Magyari, Melinda
    Sondergaard, Helle Bach
    Sellebjerg, Finn
    Sorensen, Per Soelberg
    MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2013, 2 (02) : 141 - 146
12345