IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response

被引：68
|
作者：
Leyva, L
Fernández, O
Fedetz, M
Blanco, E
Fernández, VE
Oliver, B
León, A
Pinto-Medel, MJ
Mayorga, C
Guerrero, M
Luque, G
Alcina, A
Matesanz, F
机构：
[1] Hosp Civil, Lab Invest, Malaga 29009, Spain
[2] Hosp Carlos Haya, Serv Neurol, Inst Neurociencias Clin, Malaga 29010, Spain
[3] Hosp Clin San Cecilio, Granada 18012, Spain
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 163卷 / 1-2期
关键词：
type I interferon receptor; polymorphism; multiple sclerosis; association; treatment;
D O I：
10.1016/j.jneuroim.2005.02.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFN treatment response in a group of 147 patients and 210 controls undergoing interferon therapy during the last 2 years. Only the 18417 and the 11876 SNPs showed an association with disease susceptibility (p = 0.001 and 0.035, respectively) although no differential genotype distribution were observed between interferon responders and non-responder MS patients. No alteration of the expression level of IFNAR-1 was observed with respect to the -408 genotypes or to interferon treatment response. These data suggest a role for the IFNAR pathway in susceptibility to MS. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
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