Carcinine-β-cyclodextrin derivatives as scavenger entities of •OH radicals and SOD-like properties of their copper(II) complexes

被引：12

作者：

Bonomo, Raffaele Pietro ^{[1
]}

D'Alessandro, Franca ^{[1
]}

Grasso, Giulia ^{[2
]}

Impellizzeri, Giuseppe ^{[1
]}

Pappalardo, Giuseppe ^{[2
]}

Rizzarelli, Enrico ^{[1
]}

Tabbi, Giovanni ^{[2
]}

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[2] Ist Biostrutture & Bioimmagini Sezione Catania, I-95125 Catania, Italy

来源：

INORGANICA CHIMICA ACTA | 2008年 / 361卷 / 06期

关键词：

copper; cyclodextrin derivative; carcinine; superoxide radical; hydroxyl radical;

D O I：

10.1016/j.ica.2007.01.021

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

6-Deoxy-6-{4-[N-(2-aminoethyl) propaneamide] imidazolyl} cyclohepta amylose (CDcarc) and 6-{3-amine-N-[2-(imidazol-4-yl) ethyl]propaneamide}- 6-deoxycyclohepta amylose (CDcrac) were synthesized with the aim to obtain copper(II) complexes able to scavenge superoxide radical. The copper(II) complexes were studied by means of UV-Vis, ESR, CD, ESI-MS spectroscopies to gain information about the species present in solution as function of the pH. The antioxidant activity was assayed against superoxide enzymatically generated and compared with that obtained from copper(II) complex with underivatized carcinine. The hydroxyl radical scavenging ability of these new ligands was also tested. (C) 2007 Elsevier B. V. All rights reserved.

引用

页码：1705 / 1714

页数：10

共 52 条

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