Effect of hormonal contraceptives on serum lipids: A prospective study

被引:0
作者
Dilshad, Huma [1 ,2 ]
Ismail, Rabia [1 ]
Naveed, Safila [1 ,2 ]
Usmanghani, Khan [2 ]
Alam, M. Tanweer [2 ]
Sarwar, Ghulam [2 ]
机构
[1] Univ Karachi, Fac Pharm, Karachi 32, Pakistan
[2] Jinnah Univ Women Karachi, Fac Pharm, Karachi, Pakistan
关键词
Contraception; Depo-medroxy progesterone Acetate (DMPA); Combined Oral Contraceptives (COCs) lipid profile; DEPOT-MEDROXYPROGESTERONE ACETATE; LONG-TERM USERS; ORAL-CONTRACEPTIVES; WOMEN; APOLIPOPROTEINS; CARBOHYDRATE; LIPOPROTEINS; PROVERA;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
To estimate the effects of using hormonal contraceptives on serum lipoprotein levels. Lipid profile was measured at baseline and afterward at 3, 6, 9 and 12 months. 1391 Pakistani females taking COCs, DMPA, or non hormonal (NH) contraceptives. The results were calculated by repeated measure ANOVA subsequent to tukey's post hoc test for the multiple comparisons. Statistical examination revealed that differences in lipid profile were significant (p <0.001) among all treated group in comparison with control. DMPA also caused significant rise in Castelli index-I and Castelli index-II as compared to COCs group and control group. This study demonstrated raise in total cholesterol (TC) and triglycerides (TG) as well as very low density lipoprotein (VLDL-C) and low density lipoprotein cholesterol (LDL-C). Whereas, an obvious decrease was observed in high density-lipoprotein cholesterol (HDL-C) in the DMPA-treated group. We concluded that, this inductive study specifies atherogenic cardiovascular risk in women using DMPA on long term basis.
引用
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页码:1379 / 1382
页数:4
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