A facile access to thieno[2,3-b]indoles via sulfur-mediated decarboxylative cyclization of α, β-unsaturated carboxylic acids with indoles

被引：11
|
作者：
Zhang, Hao-Lin [1 ]
Wen, Fei [1 ]
Sheng, Wen-Bing [1 ]
Yin, Peng [4 ]
Zhang, Chun-Tao [1 ]
Peng, Cai-Yun [1 ]
Peng, Dong-Ming [1 ]
Liao, Duan-Fang [1 ,2 ]
Fu, Rong-Geng [1 ,2 ,3 ]
机构：
[1] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China
[2] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China
[3] Hunan Key Lab Druggabil & Preparat Modificat Trad, Changsha 410208, Hunan, Peoples R China
[4] Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 01期
关键词：
Thieno[2,3-b]indoles; Sulfur-mediated; Decarboxylation; Cyclization; Three-component reaction; FUNCTIONALIZATION; THIOAMIDATION; AMINATION;
D O I：
10.1016/j.tetlet.2018.11.062
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of thieno[2,3-b]indoles via a one-pot three-component reaction was well established. By using inexpensive and commercial available indoles and a, a-unsaturated carboxylic acids in the presence of elemental sulfur, various functional groups were achieved in moderate to good yields. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：80 / 83
页数：4
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