A facile access to thieno[2,3-b]indoles via sulfur-mediated decarboxylative cyclization of α, β-unsaturated carboxylic acids with indoles

被引：11

作者：

Zhang, Hao-Lin ^{[1
]}

Wen, Fei ^{[1
]}

Sheng, Wen-Bing ^{[1
]}

Yin, Peng ^{[4
]}

Zhang, Chun-Tao ^{[1
]}

Peng, Cai-Yun ^{[1
]}

Peng, Dong-Ming ^{[1
]}

Liao, Duan-Fang ^{[1
,2
]}

Fu, Rong-Geng ^{[1
,2
,3
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China

[2] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China

[3] Hunan Key Lab Druggabil & Preparat Modificat Trad, Changsha 410208, Hunan, Peoples R China

[4] Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 01期

关键词：

Thieno[2,3-b]indoles; Sulfur-mediated; Decarboxylation; Cyclization; Three-component reaction; FUNCTIONALIZATION; THIOAMIDATION; AMINATION;

D O I：

10.1016/j.tetlet.2018.11.062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of thieno[2,3-b]indoles via a one-pot three-component reaction was well established. By using inexpensive and commercial available indoles and a, a-unsaturated carboxylic acids in the presence of elemental sulfur, various functional groups were achieved in moderate to good yields. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：80 / 83

页数：4

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