Cobalt-mediated macrocyclizations.: Facile synthesis of 2-oxo pyridinophanes via [2+2+2] cycloaddition of α,ω-diynes and isocyanates

被引:40
作者
Boñaga, LVR [1 ]
Zhang, HC [1 ]
Gauthier, DA [1 ]
Reddy, I [1 ]
Maryanoff, BE [1 ]
机构
[1] Johnson & Johnson Pharmaceut Res & Dev, Drug Discovery, Spring House, PA 19477 USA
关键词
D O I
10.1021/ol030096c
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Cobalt-mediated [2 + 2 + 2] cycloaddition of alpha,omega-diynes and isocyanates provides a direct approach to macrocyclic 2-oxopyridinophanes. This macrocyclization process, which proceeded most efficiently with aliphatic isocyanates, was conveniently performed at a moderate temperature (85degreesC) without irradiation or syringe-pump addition.
引用
收藏
页码:4537 / 4540
页数:4
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