Cobalt-mediated macrocyclizations.: Facile synthesis of 2-oxo pyridinophanes via [2+2+2] cycloaddition of α,ω-diynes and isocyanates

被引：40

作者：

Boñaga, LVR ^{[1
]}

Zhang, HC ^{[1
]}

Gauthier, DA ^{[1
]}

Reddy, I ^{[1
]}

Maryanoff, BE ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, Drug Discovery, Spring House, PA 19477 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 24期

关键词：

D O I：

10.1021/ol030096c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cobalt-mediated [2 + 2 + 2] cycloaddition of alpha,omega-diynes and isocyanates provides a direct approach to macrocyclic 2-oxopyridinophanes. This macrocyclization process, which proceeded most efficiently with aliphatic isocyanates, was conveniently performed at a moderate temperature (85degreesC) without irradiation or syringe-pump addition.

引用

页码：4537 / 4540

页数：4

共 48 条

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