共 45 条
A Modulatory Interleukin-10 Response to Staphylococcal Peptidoglycan Prevents Th1/Th17 Adaptive Immunity to Staphylococcus aureus
被引:82
作者:

Frodermann, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构: Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada

Chau, Thu A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada

Sayedyahossein, Samar
论文数: 0 引用数: 0
h-index: 0
机构: Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada

Toth, Judit M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada

Heinrichs, David E.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada

Madrenas, Joaquin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada
机构:
[1] Univ Western Ontario, Robarts Res Inst, London, ON N6A 5K8, Canada
关键词:
HUMAN DENDRITIC CELLS;
TOXIC-SHOCK-SYNDROME;
REGULATORY T-CELLS;
ALTERNATIVE ACTIVATION;
INNATE IMMUNITY;
RECEPTOR;
PHOSPHATIDYLINOSITOL-3;
KINASE;
MYCOBACTERIUM-TUBERCULOSIS;
MACROPHAGES;
TLR2;
D O I:
10.1093/infdis/jir276
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Toll-like receptor (TLR) 2 on antigen-presenting cells (APCs) enables these cells to recognize peptidoglycan-embedded lipopeptides and glycopolymers in the Staphylococcus aureus cell wall and mount an inflammatory response to this microbe. TLR2 signalling can also modulate immunity to S. aureus by inducing an interleukin (IL)-10 response in APCs. What determines the balance between proinflammatory and modulatory responses to S. aureus is unknown. We show that the modulatory IL-10 response preferentially occurs upon CD14- and CD36-independent TLR2 signaling, triggering PI3K activation, and is restricted to monocytes and monocyte-derived macrophages (MUs). In contrast, monocyte-derived dendritic cells (DCs) produce mostly IL-12 and IL-23. The differential APC polarization induced by staphylococcal peptidoglycan translates into differential T helper responses: MUs primarily trigger IL-10 and weak IL-17 responses, whereas DCs trigger a robust Th1/Th17 response. Exploitation of TLR2 signalling plasticity by S. aureus may explain the wide range of outcomes of human encounters with this microbe.
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页码:253 / 262
页数:10
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机构: Emory Univ, Emory Vaccine Res Ctr, Atlanta, GA 30322 USA

Unutmaz, D
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机构: Emory Univ, Emory Vaccine Res Ctr, Atlanta, GA 30322 USA

Pulendran, B
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机构: Emory Univ, Emory Vaccine Res Ctr, Atlanta, GA 30322 USA