MicroRNA reins in embryonic and cancer stem cells

被引：12
|
作者：
Mallick, Bibekanand [2 ]
Chakrabarti, Jayprokas [3 ]
Ghosh, Zhumur [1 ]
机构：
[1] CIT Scheme VIIM, Bioinformat Ctr, Bose Inst, Kolkata, India
[2] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA
[3] Indian Assoc Cultivat Sci, Jadavpur, India
来源：
RNA BIOLOGY | 2011年 / 8卷 / 03期
关键词：
microRNA; cancer; cancer stem cells; pluripotency; reprogramming; SNP; miRNA targets; ABILITY IN-VITRO; DNA ARCHITECTURAL FACTOR; MYELOID-LEUKEMIA CELLS; SELF-RENEWAL; PROSPECTIVE IDENTIFICATION; PROSTATE-CANCER; DOWN-REGULATION; MOUSE; EXPRESSION; PROLIFERATION;
D O I：
10.4161/rna.8.3.14497
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs represent a new layer of gene regulation in stem cells by controlling the molecular mechanisms that modulate stem cell fate and behavior. Such a role of microRNA is seen in embryonic stem cell as well, maintaining a delicate balance between survival, proliferation and self-renewal signals. Further, dysregulation of stem cell self-renewal is a likely requirement for the initiation and formation of cancer stem cells that probably pose resistance to current cancer treatments. In fact, the precise mechanism that regulates embryonic as well as cancer stem cell self-renewal and pluripotency remains largely unknown. Understanding the miRNA related stem cell biology and pathways offers great promise for improving stem cell mediated regenerative therapies as well as cancer therapies. Here we present some of the emerging evidences demonstrating the role of these molecular switches in embryonic and cancer stem cells.
引用
收藏
页码：415 / 426
页数：12
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