Thermosensitive copolymer coatings with enhanced wettability switching

被引:41
作者
Kurkuri, Mahaveer D. [1 ]
Nussio, Matthew R. [1 ]
Deslandes, Alec [1 ]
Voelcker, Nicolas H. [1 ]
机构
[1] Flinders Univ S Australia, Sch Chem Phys & Earth Sci, Bedford Pk, SA 5042, Australia
关键词
D O I
10.1021/la703668s
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Expanded cross-linked copolymers of poly(N-isopropylacrylamide) (PNiPAAm) and poly(acrylic acid) (PAAc) of varying monomer ratios were grafted from a crystalline silicon surface. Surface-tethered polymerization was performed at a slightly basic pH, where electrostatic repulsion among acrylic acid monomer units forces the network into an expanded polymer conformation. The influence of this expanded conformation on switchability between a hydrophilic and a hydrophobic state was investigated. Characterization of the copolymer coating was carried out by means of X-ray photoelectron spectroscopy (XPS) ellipsometry, and diffuse reflectance IR. Lower critical solution temperatures (LCSTs) of the copolymer grafts on the silicon surfaces were determined by spectrophotometry. Temperature-induced wettability changes were studied using sessile drop contact angle measurements. The surface topography was investigated by atomic force microscopy (AFM) in Milli-Q water at 25 and 40 degrees C. The reversible attachment of a fluorescently labeled model protein was studied as a function of temperature using a fluorescence microscope and a fluorescence spectrometer. Maximum switching in terms of the contact angle change around the LCST was observed at a ratio of 36:1 PNiPAArn to PAAc. The enhanced control of biointerfaces achieved by these coatings may find applications in biomaterials, biochips, drug delivery, and microfluidics.
引用
收藏
页码:4238 / 4244
页数:7
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