Collective behaviour of crown channels

被引：7

作者：

Vijayvergiya, V ^{[1
]}

Bose, D ^{[1
]}

Ghosh, P ^{[1
]}

Ghosh, S ^{[1
]}

机构：

[1] Dept Biophys, New Delhi 110021, India

来源：

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2003年 / 32卷 / 08期

关键词：

bilayer electrophysiology; collective behaviour; crown ether; ion channels; relaxation studies;

D O I：

10.1007/s00249-003-0313-z

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Collective behaviour of a crown ether channel, bis[(benzo-15-crown-5)-15-yl methyl] pimelate, in a planar lipid bilayer membrane has been studied through electrophysiological methods. A characteristic feature of these channels is their sequential opening, indicated by a uniform stepwise increase in the multi-channel current. The experimental results show that there are three modes of relaxation, of which the slowest one is attributed to the channel-channel interaction. The latter varies with the number of channels incorporated in the bilayer membrane, leading to the interpretation that crown channels behave cooperatively.

引用

页码：724 / 728

页数：5

共 21 条

[1] Unusually long open times, determined by planar bilayer conductances studies, for a synthetic tris(macrocycle) that functions as a transmembrane channel in a phospholipid bilayer [J].