Chemical Modulation of Cell Fate in Stem Cell Therapeutics and Regenerative Medicine

被引：42
|
作者：
Liu, Kai [1 ,2 ,3 ]
Yu, Chen [1 ,2 ,3 ]
Xie, Min [1 ,2 ,3 ]
Li, Ke [1 ,2 ,3 ]
Ding, Sheng [1 ,2 ,3 ]
机构：
[1] Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA
[2] Gladstone Inst, Roddenberry Ctr Stem Cell Biol & Med, San Francisco, CA 94158 USA
[3] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
来源：
CELL CHEMICAL BIOLOGY | 2016年 / 23卷 / 08期
关键词：
HUMAN PLURIPOTENT CELLS; RETINAL-PIGMENT EPITHELIUM; FUNCTIONAL HUMAN LIVER; HEPATOCYTE-LIKE CELLS; IN-VITRO GENERATION; LONG-TERM SAFETY; HEMATOPOIETIC STEM; SMALL-MOLECULE; MOUSE FIBROBLASTS; PROGENITOR CELLS;
D O I：
10.1016/j.chembiol.2016.07.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regenerative medicine aims to repair and regenerate injured tissues and restore their impaired functions. Recent developments in stem cell biology have attracted significant interest in their applications in regenerative medicine. Chemical approaches using small molecules have yielded exciting results in induction and differentiation of pluripotent stem cells, lineage conversion of somatic cells, and ex vivo as well as in vivo modulation of adult stem cells. In this review, we discuss recent progress, new insights, and future challenges of the chemical approaches in stem cell biology and regenerative medicine.
引用
收藏
页码：893 / 916
页数：24
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