Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity

被引:11
作者
Sleven, Reindert [1 ]
Lanckacker, Ellen [1 ]
Boulet, Gaelle [1 ]
Delputte, Peter [1 ]
Maes, Louis [1 ]
Cos, Paul [1 ]
机构
[1] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, Lab Microbiol Parasitol & Hyg, B-2610 Antwerp, Belgium
关键词
Onychomycosis; Topical antifungals; Drug evaluation; DERMATOPHYTE NAIL INFECTION; TERBINAFINE; AMOROLFINE; EFFICACY;
D O I
10.1016/j.mimet.2015.03.009
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A novel in vitro onychomycosis model was developed to easily predict the topical activity potential of novel antifungal drugs. The model encompasses drug activity and diffusion through bovine hoof slices in a single experimental set-up. Results correspond well with the antifungal susceptibility assay and Franz cell diffusion test. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:73 / 75
页数:3
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