Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity

被引：11
作者：
Sleven, Reindert [1 ]
Lanckacker, Ellen [1 ]
Boulet, Gaelle [1 ]
Delputte, Peter [1 ]
Maes, Louis [1 ]
Cos, Paul [1 ]
机构：
[1] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, Lab Microbiol Parasitol & Hyg, B-2610 Antwerp, Belgium
来源：
JOURNAL OF MICROBIOLOGICAL METHODS | 2015年 / 112卷
关键词：
Onychomycosis; Topical antifungals; Drug evaluation; DERMATOPHYTE NAIL INFECTION; TERBINAFINE; AMOROLFINE; EFFICACY;
D O I：
10.1016/j.mimet.2015.03.009
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel in vitro onychomycosis model was developed to easily predict the topical activity potential of novel antifungal drugs. The model encompasses drug activity and diffusion through bovine hoof slices in a single experimental set-up. Results correspond well with the antifungal susceptibility assay and Franz cell diffusion test. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：73 / 75
页数：3
相关论文
共 15 条
  • [1] Anti-infective potential of natural products: How to develop a stronger in vitro 'proof-of-concept'
    Cos, Paul
    Vlietinck, Arnold J.
    Vanden Berghe, Dirk
    Maes, Louis
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2006, 106 (03) : 290 - 302
  • [2] In Vitro Profiling of Pramiconazole and In Vivo Evaluation in Microsporum canis Dermatitis and Candida albicans Vaginitis Laboratory Models
    de Wit, Kelly
    Paulussen, Caroline
    Matheeussen, An
    van Rossem, Koen
    Cos, Paul
    Maes, Louis
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (11) : 4927 - 4929
  • [3] Espinel-Ingroff AV, 2007, MANUAL OF CLINICAL MICROBIOLOGY, 9TH ED, P1972
  • [4] Therapies for the treatment of onychomycosis
    Gupta, Aditya K.
    Paquet, Maryse
    Simpson, Fiona C.
    [J]. CLINICS IN DERMATOLOGY, 2013, 31 (05) : 544 - 554
  • [5] Prevalence and epidemiology of onychomycosis in patients visiting physicians' offices: A multicenter Canadian survey of 15,000 patients
    Gupta, AK
    Jain, HC
    Lynde, CY
    MacDonald, P
    Cooper, EA
    Summerbell, RC
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2000, 43 (02) : 244 - 248
  • [6] Infected nail plate model made of human hair keratin for evaluating the efficacy of different topical antifungal formulations against Trichophyton rubrum in vitro
    Lusiana
    Reichl, Stephan
    Mueller-Goymann, Christel C.
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 84 (03) : 599 - 605
  • [7] In-vitro permeability of the human nail and of a keratin membrane from bovine hooves: Prediction of the penetration rate of antimycotics through the nail plate and their efficacy
    Mertin, D
    Lippold, BC
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (09) : 866 - 872
  • [8] Nowrozi Hossein, 2008, Indian J Dermatol, V53, P125, DOI 10.4103/0019-5154.43216
  • [9] Antifungal drug response in an in vitro model of dermatophyte nail infection
    Osborne, CS
    Leitner, I
    Favre, B
    Ryder, NS
    [J]. MEDICAL MYCOLOGY, 2004, 42 (02) : 159 - 163
  • [10] Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection
    Schaller, Martin
    Borelli, Claudia
    Berger, Ursula
    Walker, Birgit
    Schmidt, Sybille
    Weindl, Guenther
    Jaeckel, Andreas
    [J]. MEDICAL MYCOLOGY, 2009, 47 (07) : 753 - 758
12