Micronization processes with supercritical fluids:: Fundamentals and mechanisms

被引:246
作者
Martin, A. [1 ]
Cocero, M. J. [1 ]
机构
[1] Univ Valladolid, Fac Ciencias, Dept Ingn Quim & Tecnol Medio Ambiente, Valladolid 47011, Spain
基金
欧盟地平线“2020”;
关键词
supercritical carbon dioxide; RESS; SAS; PGSS; computer simulation; mathematical modeling;
D O I
10.1016/j.addr.2007.06.019
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Supercritical fluid techniques for materials precipitation have been proposed as an alternative to conventional precipitation processes as they allow to improve the performance of these processes in terms of reduction of particle size and control of morphology and particle size distribution, without degradation or contamination of the product. These techniques have received much attention during the last years, and their feasibility and performance have been experimentally demonstrated for many substances. One of the main pending tasks is the development of a systematic procedure for the design and scale-up of these processes. This requires not only empirical knowledge, but also information about the fundamentals of the process. This work aims to review the published literature dealing with a fundamental investigation or modeling of supercritical fluid precipitation processes. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:339 / 350
页数:12
相关论文
共 54 条
[1]  
Badilla JCDF, 2000, J SUPERCRIT FLUID, V17, P13
[2]  
BERTUCCO A, 2000, HIGH PRESSURE PROCES, V9
[3]   Analysis of the supersaturation and precipitation process with supercritical CO2 [J].
Bristow, S ;
Shekunov, T ;
Shekunov, BY ;
York, P .
JOURNAL OF SUPERCRITICAL FLUIDS, 2001, 21 (03) :257-271
[4]  
Brunner G., 1994, GAS EXTRACTION
[5]  
Colussi S, 2006, J SUPERCRIT FLUID, V39, P118, DOI 10.1016/j.supflu.2006.01.012
[6]  
Czerwonatis N, 2001, CHEM ENG TECHNOL, V24, P619, DOI 10.1002/1521-4125(200106)24:6<619::AID-CEAT619>3.0.CO
[7]  
2-H
[8]   Modelling mass transfer in the PCA process using the Maxwell-Stefan approach [J].
de Diego, YP ;
Wubbolts, FE ;
Jansens, PJ .
JOURNAL OF SUPERCRITICAL FLUIDS, 2006, 37 (01) :53-62
[9]   On the selection of optimum thermodynamic conditions for the GAS process [J].
de la Fuente, JC ;
Shariati, A ;
Peters, CJ .
JOURNAL OF SUPERCRITICAL FLUIDS, 2004, 32 (1-3) :55-61
[10]   HOMOGENEOUS NUCLEATION IN SUPERCRITICAL FLUIDS [J].
DEBENEDETTI, PG .
AICHE JOURNAL, 1990, 36 (09) :1289-1298