Autologous Platelet-Rich Gel Treatment of Chronic Nonhealing Ulcerated Tophaceous Gout

被引：3

作者：

Chen, Dawei ^{[1
]}

Wang, Chun ^{[1
]}

Cui, Lina ^{[1
]}

Ran, Xingwu ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Chengdu, Sichuan, Peoples R China

来源：

INDIAN JOURNAL OF DERMATOLOGY | 2020年 / 65卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Autologous patelet-rich gel; gout; platelet-rich plasma; tophus ulcer; PLASMA;

D O I：

10.4103/ijd.IJD_157_18

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Ulcers resulting from tophaceous gout are uncommon and very difficult to heal. Here we report a case with chronic refractory tophaceous gout, not responding to conventional treatment modality for several months in a 39-year-old man with a 12-year history of gout with recurrent acute arthritis attacks. Two times after treatment with autologous platelet-rich gel (APG), the ulcer healed finally for 2 months. This is the first study to confirm that APG can improve tophus ulcer healing. Based on conventional medical therapy and standard debridement, APG might be a novel and effective method to stimulate tophus ulcer healing.

引用

页码：141 / 144

页数：4

共 19 条

[1] Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing [J].

Carter, CA ;

Jolly, DG ;

Worden, CE ;

Hendren, DG ;

Kane, CJM .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2003, 74 (03) :244-255

[2] Antibacterial Effect of Autologous Platelet-Rich Gel Derived from Subjects with Diabetic Dermal Ulcers In Vitro [J].

Chen, Lihong ;

Wang, Chun ;

Liu, Hengchuan ;

Liu, Guanjian ;

Ran, Xingwu .

JOURNAL OF DIABETES RESEARCH, 2013, 2013

[3] Elderly-onset gout: a review [J].

De Leonardis, Francesco ;

Govoni, Marcello ;

Colina, Matteo ;

Bruschi, Marco ;

Trotta, Francesco .

RHEUMATOLOGY INTERNATIONAL, 2007, 28 (01) :1-6

[4]

Fu Xiaobing, 2004, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, V18, P508

[5]

[何利平 He Liping], 2012, [四川大学学报. 医学版, Journal of Sichuan University. Medical Science Edition], V43, P757

[6] Treatment of tophaceous gout: When medication is not enough [J].

Kasper, Isaac R. ;

Juriga, Matthew D. ;

Giurini, John M. ;

Shmerling, Robert H. .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2016, 45 (06) :669-674

[7] Nonhealing Ulcers in Patients with Tophaceous Gout: A Systematic Review [J].

Lam, Gretl ;

Ross, Frank L. ;

Chiu, Ernest S. .

ADVANCES IN SKIN & WOUND CARE, 2017, 30 (05) :230-237

[8] Surgical treatment of the chronic tophaceous deformity in upper extremities - the shaving technique [J].

Lee, Su-Shin ;

Sun, I-Feng ;

Lu, Yen-Mou ;

Chang, Kao-Ping ;

Lai, Chung-Sheng ;

Lin, Sin-Daw .

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2009, 62 (05) :669-674

[9] Autologous platelet-rich gel for treatment of diabetic chronic refractory cutaneous ulcers: A prospective, randomized clinical trial [J].

Li, Lan ;

Chen, Dawei ;

Wang, Chun ;

Yuan, Nanbing ;

Wang, Yan ;

He, Liping ;

Yang, Yanzhi ;

Chen, Lihong ;

Liu, Guanjian ;

Li, Xiujun ;

Ran, Xingwu .

WOUND REPAIR AND REGENERATION, 2015, 23 (04) :495-505

[10] The Effect of Autologous Platelet-Rich Gel on the Dynamic Changes of the Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 Expression in the Diabetic Chronic Refractory Cutaneous Ulcers [J].

Li, Lan ;

Chen, Dawei ;

Wang, Chun ;

Liu, Guanjian ;

Ran, Xingwu .

JOURNAL OF DIABETES RESEARCH, 2015, 2015

← 1 2 →