Protein kinase affinity reagents based on a 5-aminoindazole scaffold

被引：6

作者：

Krishnamurty, Ratika ^{[1
]}

Brock, Amanda M. ^{[1
]}

Maly, Dustin J. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Protein kinase; Affinity reagent; Structure-activity relationship; Indazole; Pharmacophore; CELLULAR TARGETS; INHIBITOR;

D O I：

10.1016/j.bmcl.2010.10.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding elements and immobilized analogs allow selective enrichment of protein kinases from complex mixtures. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：550 / 554

页数：5

共 21 条

[1] Toward a pharmacophore for kinase frequent hitters [J].

Aronov, AM ;

Murcko, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (23) :5616-5619

[2] Roscovitine targets, protein kinases and pyridoxal kinase [J].

Bach, S ;

Knockaert, M ;

Reinhardt, J ;

Lozach, O ;

Schmitt, S ;

Baratte, B ;

Koken, M ;

Coburn, SP ;

Tang, L ;

Jiang, T ;

Liang, DC ;

Galons, H ;

Dierick, JF ;

Pinna, LA ;

Meggio, F ;

Totzke, F ;

Schächtele, C ;

Lerman, AS ;

Carnero, A ;

Wan, YQ ;

Gray, N ;

Meijer, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (35) :31208-31219

[3] Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors [J].

Bantscheff, Marcus ;

Eberhard, Dirk ;

Abraham, Yann ;

Bastuck, Sonja ;

Boesche, Markus ;

Hobson, Scott ;

Mathieson, Toby ;

Perrin, Jessica ;

Raida, Manfred ;

Rau, Christina ;

Reader, Valerie ;

Sweetman, Gavain ;

Bauer, Andreas ;

Bouwmeester, Tewis ;

Hopf, Carsten ;

Kruse, Ulrich ;

Neubauer, Gitte ;

Ramsden, Nigel ;

Rick, Jens ;

Kuster, Bernhard ;

Drewes, Gerard .

NATURE BIOTECHNOLOGY, 2007, 25 (09) :1035-1044

[4] Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors [J].

Brehmer, D ;

Godl, K ;

Zech, B ;

Wissing, J ;

Daub, H .

MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (05) :490-500

[5]

Brehmer D, 2005, CANCER RES, V65, P379

[6] Protein kinases - the major drug targets of the twenty-first century? [J].

Cohen, P .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (04) :309-315

[7] Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle [J].

Daub, Henrik ;

Olsen, Jesper V. ;

Bairlein, Michaela ;

Gnad, Florian ;

Oppermann, Felix S. ;

Koerner, Roman ;

Greff, Zoltan ;

Keri, Gyoergy ;

Stemmann, Olaf ;

Mann, Matthias .

MOLECULAR CELL, 2008, 31 (03) :438-448

[8] A small molecule-kinase interaction map for clinical kinase inhibitors [J].

Fabian, MA ;

Biggs, WH ;

Treiber, DK ;

Atteridge, CE ;

Azimioara, MD ;

Benedetti, MG ;

Carter, TA ;

Ciceri, P ;

Edeen, PT ;

Floyd, M ;

Ford, JM ;

Galvin, M ;

Gerlach, JL ;

Grotzfeld, RM ;

Herrgard, S ;

Insko, DE ;

Insko, MA ;

Lai, AG ;

Lélias, JM ;

Mehta, SA ;

Milanov, ZV ;

Velasco, AM ;

Wodicka, LM ;

Patel, HK ;

Zarrinkar, PP ;

Lockhart, DJ .

NATURE BIOTECHNOLOGY, 2005, 23 (03) :329-336

[9] Global analysis of protein expression in yeast [J].

Ghaemmaghami, S ;

Huh, W ;

Bower, K ;

Howson, RW ;

Belle, A ;

Dephoure, N ;

O'Shea, EK ;

Weissman, JS .

NATURE, 2003, 425 (6959) :737-741

[10] An efficient proteomics method to identify the cellular targets of protein kinase inhibitors [J].

Godl, K ;

Wissing, J ;

Kurtenbach, A ;

Habenberger, P ;

Blencke, S ;

Gutbrod, H ;

Salassidis, K ;

Stein-Gerlach, M ;

Missio, A ;

Cotten, M ;

Daub, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) :15434-15439

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