In Vitro Oxidation of Fibrinogen Promotes Functional Alterations and Formation of Advanced Oxidation Protein Products, an Inflammation Mediator

被引：14
作者：
Torbitz, Vanessa Dorneles [1 ,2 ]
Bochi, Guilherme Vargas [1 ,3 ]
Mainardi de Carvalho, Jose Antonio [1 ,2 ]
Vaucher, Rodrigo de Almeida [4 ]
Paz da Silva, Jose Edson [2 ]
Moresco, Rafael Noal [1 ,2 ,3 ]
机构：
[1] Univ Fed Santa Maria, Ctr Hlth Sci, Dept Clin & Toxicol Anal, Lab Clin Biochem, BR-97119900 Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Ctr Hlth Sci, Pharmaceut Sci Postgrad Program, BR-97119900 Santa Maria, RS, Brazil
[3] Univ Fed Santa Maria, Ctr Hlth Sci, Pharmacol Postgrad Program, BR-97119900 Santa Maria, RS, Brazil
[4] Franciscan Univ Ctr, Ctr Hlth Sci, Microbiol Lab, Santa Maria, RS, Brazil
来源：
INFLAMMATION | 2015年 / 38卷 / 03期
关键词：
advanced oxidation protein products; coagulation; fibrinogen; inflammation; oxidative stress; CARDIOVASCULAR-DISEASE; CRYSTAL-STRUCTURE; POLYMERIZATION; STRESS; RISK;
D O I：
10.1007/s10753-014-0085-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fibrinogen (FB) is a soluble blood plasma protein and is a key molecule involved in coagulation. Oxidative modification of proteins, such as the formation of advanced oxidation protein products (AOPP), a heterogeneous family of protein compounds structurally modified and derived from oxidative stress, may be associated with the pathophysiology of a number of chronic inflammatory diseases. Therefore, the aim of this study was to determine whether the formation of this mediator of inflammation occurs from FB and whether its generation is associated with structural changes. Results of the present study suggest that the oxidation of FB may provoke the formation of AOPP, which in turn, may promote functional alterations in FB, thus causing changes in its structural domains and increasing its procoagulant activity.
引用
收藏
页码：1201 / 1206
页数：6
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