Expression of BMP-4 mRNA during distraction osteogenesis in rabbits

被引：51

作者：

Li, G ^{[1
]}

Berven, S

Simpson, H

Triffitt, JT

机构：

[1] Univ Oxford, Nuffield Orthopaed Ctr, Nuffield Dept Orthopaed Surg, Oxford OX3 7LD, England

[2] Massachusetts Gen Hosp, Dept Orthoped Surg, Boston, MA 02115 USA

[3] Nuffield Orthopaed Ctr, MRC, Bone Res Lab, Oxford OX3 7LD, England

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1998年 / 69卷 / 04期

关键词：

D O I：

10.3109/17453679808999060

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.

引用

页码：420 / 425

页数：6