Treatment with LEDs at a wavelength of 642 nm enhances skin tumor proliferation in a mouse model

被引：6

作者：

Goo, Hyeyoon ^{[1
,2
]}

Mo, SangJoon ^{[2
]}

Park, Hyeong Ju ^{[2
]}

Lee, Min Young ^{[2
,3
,4
]}

Ahn, Jin-Chul ^{[1
,2
,4
]}

机构：

[1] Dankook Univ, Grad Sch Med, Dept Med Laser, Cheonan 31116, South Korea

[2] Dankook Univ, Med Laser Res Ctr, Cheonan 31116, South Korea

[3] Dankook Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Cheonan 31116, South Korea

[4] Dankook Univ, Beckman Laser Inst Korea, Cheonan 31116, South Korea

来源：

BIOMEDICAL OPTICS EXPRESS | 2021年 / 12卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

OPTICAL-PROPERTIES; LASER; LIGHT; CARCINOMA; RADIATION; PHOTOTHERAPY; EFFICACY; THERAPY; RANGE;

D O I：

10.1364/BOE.427205

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Photobiomodulation (PBM) is attracting increased attention in the fields of dermatology and cosmetics. PBM with a variety of light parameters has been used widely in skin care, but can cause certain types of unwanted cells to proliferate in the skin; this can lead to skin tumors, such as papillomas and cancers. We constructed a mouse model of human skin tumors using DMBA as an initiator and TPA as a promoter, and confirmed that LEDs with a wavelength of 642 nm (red light) increased tumor size, epidermal thickness, and systemic proinflammatory cytokine levels. These results indicated that skin tumor cell proliferation may result from the use of 642 nm LEDs, suggesting the need for regulation of skin care based on LED light therapy. (c) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：5583 / 5596

页数：14

共 38 条

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