The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity

被引：0

作者：

Kuchroo, Juhi R. ^{[1
,2
,3
]}

Hafler, David A. ^{[4
,5
,6
]}

Sharpe, Arlene H. ^{[1
,2
,3
,6
,7
,8
]}

Lucca, Liliana E. ^{[4
,5
]}

机构：

[1] Harvard Med Sch, Dept Immunol, Blavatnik Inst, Boston, MA 02115 USA

[2] Harvard Med Sch, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[4] Yale Sch Med, Dept Neurol, New Haven, CT 06510 USA

[5] Yale Sch Med, Dept Immunobiol, New Haven, CT 06510 USA

[6] Broad Inst MIT & Harvard Univ, Cambridge, MA USA

[7] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA

[8] Harvard Med Sch, Boston, MA 02115 USA

来源：

SCIENCE IMMUNOLOGY | 2021年 / 6卷 / 65期

关键词：

T-CELL EXHAUSTION; REGULATORY T; INHIBITORY RECEPTORS; PHOSPHOINOSITIDE; 3-KINASE; COINHIBITORY PATHWAYS; PROGRAMMED DEATH-1; IMMUNE-RESPONSE; GUT MICROBIOTA; ADVERSE EVENTS; CUTTING EDGE;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune checkpoint blockade has demonstrated success in treating cancer but can lead to immune-related adverse events (irAEs), illustrating the centrality of these pathways in tolerance. Here, we describe programmed cell death protein 1 (PD-1) control of T cell responses, focusing on its unique restraint of regulatory T cell function. We examine successes and limitations of checkpoint blockade immunotherapy and review clinical and mechanistic features of irAEs. Last, we discuss strategies to modulate PD-1 blockade to enhance antitumor immunity while limiting autoimmunity.

引用

页数：15

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