Serum exosomes of chronic gastritis patients infected with Helicobacter pylori mediate IL-1α expression via IL-6 trans-signalling in gastric epithelial cells

被引：42

作者：

Chen, Y. ^{[1
]}

Wang, X. ^{[1
]}

Yu, Y. ^{[1
]}

Xiao, Y. ^{[1
]}

Huang, J. ^{[1
]}

Yao, Z. ^{[2
]}

Chen, X. ^{[1
]}

Zhou, T. ^{[1
]}

Li, P. ^{[1
]}

Xu, C. ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Pediat, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp North, Dept Pediat, Shanghai, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2018年 / 194卷 / 03期

基金：

中国国家自然科学基金;

关键词：

exosomes; Helicobacter pylori; IL-1; alpha; IL-6; sIL-6R; SOLUBLE INTERLEUKIN-6 RECEPTOR; EXTRACELLULAR VESICLES; IMMUNE-RESPONSES; CANCER; INFLAMMATION; CHILDREN; MICROVESICLES; EPIDEMIOLOGY; DISEASES; ALPHA;

D O I：

10.1111/cei.13200

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Emerging evidence has linked the exosomes to many immunological disorders, including infectious diseases. However, knowledge regarding the role of exosomes in Helicobacter pylori infection is limited. Here, we show that serum exosomes from chronic gastritis patients with H. pylori infection (Hp exosomes) stimulate the expression of the soluble interleukin (IL)-6 receptor (sIL-6R), which is involved in IL-6 trans-signalling in gastric epithelial cells. Interestingly, sIL-6R up-regulates expression of the proinflammatory cytokine IL-1 alpha, and the neutralization of sIL-6R suppresses IL-1 alpha secretion. Thus, Hp exosomes regulate IL-1 alpha expression via sIL-6R-mediated IL-6 trans-signaling. Altogether, this study reveals a novel perspective in which exosomes play a vital role in immunological mechanisms during H. pylori infection.

引用

页码：339 / 349

页数：11

共 24 条

[21] Luteolin alters MUC1 extracellular domain, sT antigen, ADAM-17, IL-8, IL-10 and NF-κB expression in Helicobacter pylori-infected gastric cancer CRL-1739 cells: A preliminary study [J].

Radziejewska, Iwona ;

Borzym-Kluczyk, Malgorzata ;

Leszczynska, Katarzyna .

BIOMEDICAL REPORTS, 2021, 14 (02) :1-9

[22] The phenyl-thiophenyl propenone RK-I-123 reduces the levels of reactive oxygen species and suppresses the activation of NF-κB and AP-1 and IL-8 expression in Helicobacter pylori-infected gastric epithelial AGS cells [J].

Sung Hee Jang ;

Soonok Cho ;

Eung-Seok Lee ;

Jung Mogg Kim ;

Hyeyoung Kim .

Inflammation Research, 2013, 62 :689-696

[23] The phenyl-thiophenyl propenone RK-I-123 reduces the levels of reactive oxygen species and suppresses the activation of NF-κB and AP-1 and IL-8 expression in Helicobacter pylori-infected gastric epithelial AGS cells [J].

Jang, Sung Hee ;

Cho, Soonok ;

Lee, Eung-Seok ;

Kim, Jung Mogg ;

Kim, Hyeyoung .

INFLAMMATION RESEARCH, 2013, 62 (07) :689-696

[24] ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins [J].

Al-Ismaeel, Qais ;

Neal, Christopher P. ;

Al-Mahmoodi, Hanaa ;

Almutairi, Zamzam ;

Al-Shamarti, Ibtihal ;

Straatman, Kees ;

Jaunbocus, Nabil ;

Irvine, Andrew ;

Issa, Eyad ;

Moreman, Catherine ;

Dennison, Ashley R. ;

Sayan, A. Emre ;

McDearmid, Jonathan ;

Greaves, Peter ;

Tulchinsky, Eugene ;

Kriajevska, Marina .

BRITISH JOURNAL OF CANCER, 2019, 121 (01) :65-75

← 1 2 3 →