Serum exosomes of chronic gastritis patients infected with Helicobacter pylori mediate IL-1α expression via IL-6 trans-signalling in gastric epithelial cells

被引：40
|
作者：
Chen, Y. [1 ]
Wang, X. [1 ]
Yu, Y. [1 ]
Xiao, Y. [1 ]
Huang, J. [1 ]
Yao, Z. [2 ]
Chen, X. [1 ]
Zhou, T. [1 ]
Li, P. [1 ]
Xu, C. [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Pediat, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp North, Dept Pediat, Shanghai, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2018年 / 194卷 / 03期
基金：
中国国家自然科学基金;
关键词：
exosomes; Helicobacter pylori; IL-1; alpha; IL-6; sIL-6R; SOLUBLE INTERLEUKIN-6 RECEPTOR; EXTRACELLULAR VESICLES; IMMUNE-RESPONSES; CANCER; INFLAMMATION; CHILDREN; MICROVESICLES; EPIDEMIOLOGY; DISEASES; ALPHA;
D O I：
10.1111/cei.13200
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Emerging evidence has linked the exosomes to many immunological disorders, including infectious diseases. However, knowledge regarding the role of exosomes in Helicobacter pylori infection is limited. Here, we show that serum exosomes from chronic gastritis patients with H. pylori infection (Hp exosomes) stimulate the expression of the soluble interleukin (IL)-6 receptor (sIL-6R), which is involved in IL-6 trans-signalling in gastric epithelial cells. Interestingly, sIL-6R up-regulates expression of the proinflammatory cytokine IL-1 alpha, and the neutralization of sIL-6R suppresses IL-1 alpha secretion. Thus, Hp exosomes regulate IL-1 alpha expression via sIL-6R-mediated IL-6 trans-signaling. Altogether, this study reveals a novel perspective in which exosomes play a vital role in immunological mechanisms during H. pylori infection.
引用
收藏
页码：339 / 349
页数：11
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