Synthesis and antituberculosis activity of new fatty acid amides

被引：57

作者：

Montes D'Oca, Caroline Da Ros ^{[1
]}

Coelho, Tatiane ^{[2
]}

Marinho, Tamara Germani ^{[1
]}

Lopes Hack, Carolina Rosa ^{[1
]}

Duarte, Rodrigo da Costa ^{[1
]}

da Silva, Pedro Almeida ^{[2
]}

Montes D'Oca, Marcelo Goncalves ^{[1
]}

机构：

[1] Univ Fed Rio Grande, Escola Quim & Alimentos, Lab Kolbe Sintese Organ, Rio Grande, RS, Brazil

[2] Univ Fed Rio Grande, Fac Med, Lab Micobacteriol, Rio Grande, RS, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 17期

关键词：

Mycobacterium tuberculosis; Fatty acid amides; Ricinoleic acid; FAMEs; ENDOCANNABINOID SYSTEM; MYCOBACTERIUM-TUBERCULOSIS; ANANDAMIDE; OLEAMIDE; CANCER; TARGET;

D O I：

10.1016/j.bmcl.2010.06.149

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This work reports the synthesis of new fatty acid amides from C16: 0, 18: 0, 18: 1, 18: 1 (OH), and 18: 2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 mu g/mL for resistance strains. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5255 / 5257

页数：3

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