SAC3D1: a novel prognostic marker in hepatocellular carcinoma

被引：49

作者：

Han, Myoung-Eun ^{[1
]}

Kim, Ji-Young ^{[1
]}

Kim, Ga Hyun ^{[1
]}

Park, Siyoung ^{[1
]}

Kim, Yun Hak ^{[1
,2
]}

Oh, Sae-Ock ^{[1
]}

机构：

[1] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan, South Korea

[2] Busan Soc Evidence Based mEd & Res, BEER, Busan, South Korea

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

基金：

新加坡国家研究基金会;

关键词：

GERMINAL CENTER; AURORA-A; CANCER; CELL; THERAPY; TPX2; OVEREXPRESSION; PROLIFERATION; PROGRESSION; EXPRESSION;

D O I：

10.1038/s41598-018-34129-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Centrosome-associated proteins are recognized as prognostic factors in many cancers because centrosomes are critical structures for the cell cycle progression and genomic stability. SAC3D1, however, is associated with centrosome abnormality, although its prognostic potential has not been evaluated in hepatocellular carcinoma (HCC). In this study, 3 independent cohorts (GSE10186, n = 80; TCGA, n = 330 and ICGC, n = 237) were used to assess SAC3D1 as a biomarker, which demonstrated SAC3D1 overexpression in HCC tissues when compared to the matched normal tissues. Kaplan-Meier survival analysis also showed that its overexpression was associated with poor prognosis of HCC with good discriminative ability in 3 independent cohorts (GSE10186, P = 0.00469; TCGA, P = 0.0000413 and ICGC, P = 0.0000114). Analysis of the C-indices and AUC values further supported its discriminative ability. Finally, multivariate analysis confirmed its prognostic significance (GSE10186, P = 0.00695; TCGA, P = 0.0000289 and ICGC, P = 0.0000651). These results suggest a potential of SAC3D1 as a biomarker for HCC.

引用

页数：8

共 40 条

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