Application of Biologics in the Treatment of the Rotator Cuff, Meniscus, Cartilage, and Osteoarthritis

被引：55

作者：

Anz, Adam W. ^{[1
]}

Hackel, Joshua G. ^{[1
]}

Nilssen, Erik C. ^{[1
]}

Andrews, James R. ^{[1
]}

机构：

[1] Andrews Res & Educ Inst, Gulf Breeze, FL 32561 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS | 2014年 / 22卷 / 02期

关键词：

PLATELET-RICH PLASMA; MESENCHYMAL STEM-CELLS; RANDOMIZED CONTROLLED-TRIAL; BONE-MARROW; ARTHROSCOPIC REPAIR; ARTICULAR-CARTILAGE; HYALURONIC-ACID; ADIPOSE-TISSUE; KNEE OSTEOARTHRITIS; PERIPHERAL-BLOOD;

D O I：

10.5435/JAAOS-22-02-68

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Advances in our knowledge of cell signaling and biology have led to the development of products that may guide the healing/regenerative process. Therapies are emerging that involve growth factors, blood-derived products, marrow-derived products, and stem cells. Animal studies suggest that genetic modification of stem cells will be necessary; studies of cartilage and meniscus regeneration indicate that immature cells are effective and that scaffolds are not always necessary. Current preclinical animal and clinical human data and regulatory requirements are important to understand in light of public interest in these products.

引用

收藏

页码：68 / 79

页数：15

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