MiRNAs of peripheral blood as the biomarker of schizophrenia

被引：45
作者：
He, Kuanjun [1 ]
Guo, Chuang [1 ]
He, Lin [2 ,3 ,4 ]
Shi, Yongyong [2 ,3 ,4 ]
机构：
[1] Inner Mongolia Univ Nationalities, Coll Life Sci, Tongliao 028043, Inner Mongolia, Peoples R China
[2] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ,Collaborat Innovat Ctr Brain Sci, Shanghai 200030, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
[4] Shanghai Jiao Tong Univ, Inst Neuropsychiat Sci & Syst Biol Med, Shanghai 200042, Peoples R China
来源：
HEREDITAS | 2017年 / 155卷
关键词：
Schizophrenia; Biomarkers; Peripheral MiRNAs; Significance and values; MICRORNA EXPRESSION; ABERRANT EXPRESSION; PREFRONTAL CORTEX; HAN CHINESE; GENE; TARGET; SUSCEPTIBILITY; DISORDER; DISEASES; CACNA1C;
D O I：
10.1186/s41065-017-0044-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contemporary research, because they improve diagnostic accuracy. Biomarkers reflect the physiological, physical and biochemical status of the body, and so have extensive applicability and practical significance. The ascertainment of schizophrenia biomarkers will help diagnose, stratify of disease, and treat of schizophrenia patients. The detection of biomarkers from blood has become a promising area of schizophrenia research. Recently, a series of studies revealed that, MiRNAs play an important role in the genesis of schizophrenia, and their abnormal expressions have the potential to be used as biomarkers of schizophrenia. This article presents and summarizes the value of peripheral blood miRNAs with abnormal expression as the biomarker of schizophrenia.
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页码：1 / 5
页数：5
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