Remarkable facilitation of hetero-cycloisomerizations with water and other polar protic solvents: metal-free synthesis of indolizines

被引：28

作者：

Narayan, Alison R. Hardin ^{[1
]}

Sarpong, Richmond ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

GREEN CHEMISTRY | 2010年 / 12卷 / 09期

关键词：

ORGANIC-REACTIONS; CATALYZED CYCLOISOMERIZATION; ACCELERATION; PYRROLONES; ACTIVATION; INHIBITORS;

D O I：

10.1039/c0gc00198h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hetero-cycloisomerization reactions of propargylic alcohol derivatives leading to indolizines have been demonstrated to proceed in the presence of water alone. This stands as a significant advance over the previous methods using Pt, Cu or Ag salts paired with ligands in organic solvents such as benzene, acetonitrile or methylene chloride.

引用

页码：1556 / 1559

页数：4

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